Inhibitors

Isturisa; (+)-Osilodrostat; (R)-4-(6,7-Dihydro-5H-Pyrrolo[1,2-c]Imidazol-5-yl)-3-Fluorobenzonitrile; 4-[(5R)-6,7-Dihydro-5H-Pyrrolo[1,2-c]Imidazol-5-yl]-3-Fluorobenzonitrile; 4-[(4R,5R)-6,7-Dihydro-5H-Pyrrolo[1,2-c]Imidazol-5-yl]-3-Fluorobenzonitrile; Benzonitrile, 4-((5R)-6,7-Dihydro-5H-Pyrrolo(1,2-c)Imidazol-5-yl)-3-Fluoro-; C1CC2=CN=CN2[C@H]1C3=C(C=C(C=C3)C; N)F

Tryptamicidin; Zepzelca; [(1R,2R,3R,11S,12S,14R,26R)-5,12-Dihydroxy-6,6'-Dimethoxy-7,21,30-Trimethyl-27-Oxospiro[17,19,28-Trioxa-24-thia-13,30-Diazaheptacyclo[12.9.6.13,11.02,13.04,9.015,23.016,20]Triaconta-4(9),5,7,15,20,22-Hexaene-26,1'-2,3,4,9-Tetrahydropyrido[3,4-b]Indole]-22-yl] Acetate; Zepsyre; (1'R,6R,6AR,7R,13S,14S,16R)-8,14-Dihydroxy-6',9-Dimethoxy-4,10,23-Trimethyl-19-OXO-2',3',4',6,7,9',12,13,14,16-Decahydro-6Ahspiro(7,13-Azano-6,16-(Epithiopropanooxymethano)(1,3)Dioxolo(7,8)Isoquinolino(3,2-B)(3)Benzazocine-20,1'-Pyrido(3,4-B)Indol)-5-YL Acetate; [(1R,2R,3R,11S,12S,14R,26R)-5,12-Dihydroxy-6,6'-Dimethoxy-7,21,30-Trimethyl-27-Oxospiro[17,19,28-Trioxa-24-thia-13,30-Diazaheptacyclo[12.9.6.13,11.02,13.04,9.015,23.016,20]Triaconta-4(9),5,7,15,20,22-Hexaene-26,1'-2,3,4,9-Tetrahydropyrido[3,4-b]Indole]-22; Spiro(6,16-(Epithiopropanoxymethano)-7,13-Imino-12H-1,3-Dioxolo(7,8)Isoquino(3,2-B)(3)Benzazocine-20,1'-(1H)Pyrido(3,4-B)Indol)-19-ONE, 5-(Acetyloxy)-2',3',4',6,6A,7,9',13,14,16-Decahydro-8,14-Dihydroxy-6',9-Dimethoxy-4,10,23-Trimethyl-, (1'R,6R,6AR,7R,13S,14S,16R)-; Lurbinectidine

MRTX849; MRTX-849; 2-((S)-4-(7-(8-Chloronaphthalen-1-yl)-2-(((S)-1-Methylpyrrolidin-2-yl)Methoxy)-5,6,7,8-Tetrahydropyrido[3,4-d]Pyrimidin-4-yl)-1-(2-Fluoroacryloyl)Piperazin-2-yl)Acetonitrile; 2-[(2S)-4-[7-(8-Chloronaphthalen-1-yl)-2-[[(2S)-1-Methylpyrrolidin-2-yl]Methoxy]-6,8-Dihydro-5H-Pyrido[3,4-d]Pyrimidin-4-yl]-1-(2-Fluoroprop-2-Enoyl)Piperazin-2-yl]Acetonitrile; 2-Piperazineacetonitrile, 4-[7-(8-Chloro-1-Naphthalenyl)-5,6,7,8-Tetrahydro-2-[[(2S)-1-Methyl-2-Pyrrolidinyl]Methoxy]Pyrido[3,4-d]Pyrimidin-4-yl]-1-(2-Fluoro-1-oxo-2-Propen-1-yl)-, (2S)-; ((2S)-4-(7-(8-Chloronaphthalen-1-YL)-2-(((2S)-1- Methylpyrrolidin-2-YL)Methoxy)-5,6,7,8- Tetrahydropyrido(3,4-D)Pyrimidin-4-YL)-1-(2-Fluoroprop2-Enoyl)Piperazin-2-YL)Acetonitrile; [(2S)-4-[7-(8-Chloro-1-Naphthyl)-2-{[(2S)-1-Methyl-2-Pyrrolidinyl]Methoxy}-5,6,7,8-Tetrahydropyrido[3,4-d]Pyrimidin-4-yl]-1-(2-Fluoroacryloyl)-2-Piperazinyl]Acetonitrile

RO5126766; RO-5126766; Avutometinib; Ro 5126766; N-(3-Fluoro-4-{[4-Methyl-2-Oxo-7-(Pyrimidin-2-Yloxy)-2h-Chromen-3-Yl]Methyl}Pyridin-2-Yl)-N'-Methylsulfuric Diamide; Sulfamide, N-(3-Fluoro-4-((4-Methyl-2-oxo-7-(2-Pyrimidinyloxy)-2H-1-Benzopyran-3-yl)Methyl)-2-Pyridinyl)-N'-Methyl-; 3-[(2-((N-Methylsulfamoyl)Amino)-3-Fluoropyridin-4-yl)Methyl]-4-Methyl-7-(Pyrimidin-2-Yloxy)-Chromen-2-one; 3-[[3-Fluoro-2-(Methylsulfamoylamino)Pyridin-4-yl]Methyl]-4-Methyl-7-Pyrimidin-2-Yloxychromen-2-one; N-(3-Fluoro-4-((4-Methyl-2-OXO-7-(Pyrimidin-2-Yloxy)-2H-Chromen-3-YL)Methyl)Pyridin-2-YL)-N'-Methylsulfamide

N-(3-Bromo-4-Fluorophenyl)-N'-Hydroxy-4-{[2-(Sulfamoylamino)Ethyl]Amino}-1,2,5-Oxadiazole-3-Carboximidamide; (Z)-N-(3-Bromo-4-Fluorophenyl)-N'-Hydroxy-4-[2-(Sulfamoylamino)Ethylamino]-1,2,5-Oxadiazole-3-Carboxamidine; 1,2,5-Oxadiazole-3-Carboximidamide, 4-((2-((Aminosulfonyl)Amino)Ethyl)Amino)-N-(3-Bromo-4-Fluorophenyl)-N'-Hydroxy-, (C(Z))-; N'-(3-Bromo-4-Fluorophenyl)-N-Hydroxy-4-((2-(Sulfamoylamino)Ethyl)Amino)-1,2,5-Oxadiazole-3-Carboximidamide; N-(3-Bromo-4-Fluorophenyl)-N'-Hydroxy-4-{[2-(Sulfamoylamino)Ethyl]Amino}-1,2,5-Oxadiazole-3- Carboxi; (3E)-3-[(3-Bromo-4-Fluoroanilino)-Nitrosomethylidene]-4-[2-(Sulfamoylamino)Ethylamino]-1,2,5-Oxadiazole; (Z)-N-(3-Bromo-4-Fluorophenyl)-N Inverted Exclamation mark -Hydroxy-4-[[2-(Sulfamoylamino)Ethyl]Amino]-1,2,5-Oxadiazole-3-Carboxamidine; (Z)-N-(3-Bromo-4-Fluorophenyl)-N'-Hydroxy-4-((2-(Sulfamoylamino)Ethyl)Amino)-1,2,5-Oxadiazole-3-Carboximidamide; (Z)-N-(3-Bromo-4-Fluorophenyl)-N'-Hydroxy-4-(2- (Sulfamoylamino)Ethylamino)-1,2,5-Oxadiazole-3-Carboxamidine; (Z)-N-(3-Bromo-4-Fluorophenyl)-N'-Hydroxy-4-(2-(Sulfamoylamino)Ethylamino)-1,2,5-Oxadiazole-3-Carboximidamide; 1,2,5-Oxadiazole-3-Carboximidamide, 4-((2-((Aminosulfonyl)Amino)Ethyl)Amino)-N'-(3-Bromo-4-Fluorophenyl)-N-Hydroxy-; 1,2,5-Oxadiazole-3-Carboximidamide, 4-((2-((Aminosulfonyl)Amino)Ethyl)Amino)-N-(3-Bromo-4-Fluorophenyl)-N'-Hydroxy-; 1,2,5-Oxadiazole-3-Carboximidamide, 4-[[2-[(Aminosulfonyl)Amino]Ethyl]Amino]-N-(3-Bromo-4-Fluorophenyl)-N-Hydroxy-, [C(Z)]-; 4-({2-[(Aminosulfonyl)Amino]Ethyl}Amino)-N-(3-Bromo-4-Fluorophenyl)-N'-Hydroxy-1,2,5-Oxadiazole-3-Carboximidamide; N-(3-Bromo-4-Fluoro-Phenyl)-N'-Hydroxy-4-[2-(Sulfamoylamino)Ethylamino]-1,2,5-Oxadiazole-3-Carboxamidine; N-(3-Bromo-4-Fluorophenyl)-N'-Hydroxy-4-[[2-(Sulfamoylamino)Ethyl]Amino]-1,2,5-Oxadiazole-3-Carboxamidine; N-(3-Bromo-4-Fluorophenyl)-N'-Hydroxy-4-[2-(Sulfamoylamino)Ethylamino]-1,2,5-Oxadiazole-3-Carboxamidine; N-(3-Bromo-4-Fluorophenyl)-N'-Hydroxy-4-{[2-(Sulfamoylamino)Ethyl]Amino}-1,2,5-Oxadiazole-3- Carboximidamide