Circulatory System Drugs

Valsartan is a specific angiotensin Ⅱ (AT1) receptor antagonist. It is also a non skin AT1 receptor antagonist after losartan. It plays a key role in regulating systemic blood pressure and maintaining electrolyte and body fluid balance. It selectively acts on AT1 receptor subtypes and blocks the binding of Ang Ⅱ to AT1 receptor (its specific antagonistic effect against AT1 receptor is about 20000 times greater than that of AT2 receptor), thus inhibiting vasoconstriction and aldosterone release, resulting in hypotensive effect, but not inhibiting aldosterone release induced by potassium ion (K +). The antihypertensive effect is superior to enalapril in the treatment of hypertension, mild to moderate essential hypertension, especially for secondary hypertension caused by kidney damage. It can significantly reduce proteinuria in hypertensive patients with normal diabetes or normal renal function, and has the protective effect of promoting uric acid and urinary sodium excretion. It is also suitable for reducing the cardiovascular mortality of high-risk patients (left ventricular failure or left ventricular dysfunction) after heart attack.

Atorvastatin calcium is a HMG CoA reductase inhibitor. Mainly through inhibiting the synthesis of HMGCoA reductase, thus inhibiting the synthesis of cholesterol in vivo, reducing the content of serum low density lipoprotein cholesterol and triglyceride. Atorvastatin calcium can inhibit the synthesis of cholesterol, interfere with the production of lipoprotein, reduce the level of serum total cholesterol, effectively reduce the level of serum triglyceride, but also increase the level of serum high-density lipoprotein cholesterol. It can reduce the plasma LDL-C level in some homozygous familial hypercholesterolemia patients, but this type of population has little response to other lipid-lowering drugs. It is clinically used for primary hypercholesterolemia, mixed hyperlipidemia, hypertriglyceridemia, homozygous familial hypercholesterolemia and prevention and treatment of atherosclerosis.

Irbesartan is an angiotensin II receptor inhibitor, which can be divided into AT1 and AT2. Irbesartan can inhibit the transformation of Ang Ⅰ into ang Ⅱ by selectively blocking the AT1 receptor of ANGLI, and specifically antagonize the angiotensin converting enzyme 1 receptor. The antagonism of irbesartan to AT1 is 8500 times that of AT2, It can inhibit the vasoconstriction and the release of aldosterone. This product does not inhibit angiotensin converting enzyme, renin, other hormone receptors, and ion channels related to blood pressure regulation and sodium balance. Irbesartan is the most effective drug in the treatment of hypertension and cardiovascular disease.

This product can be widely used in food, cosmetics, dietary supplements and other industries. Coenzyme drugs are also important antioxidants and immune enhancers.

Nifedipine is a dihydropyridine calcium antagonist, which can inhibit the Ca2 + uptake of myocardium and vascular smooth muscle, dilate coronary artery, increase coronary blood flow, improve myocardial tolerance to ischemia, dilate peripheral small arteries, reduce peripheral vascular resistance, relieve coronary artery spasm, increase coronary blood flow, improve myocardial hypoxia, and reduce blood pressure. Low dose coronary artery dilation does not affect blood pressure, so it is a good anti angina drug. For the prevention and treatment of angina pectoris of coronary heart disease, it has no adverse effect on respiratory function, especially for angina pectoris caused by coronary artery spasm and angina pectoris with respiratory obstructive disease, the effect is the best, and its curative effect is better than that of traditional Chinese medicine β Receptor blockers. It is also suitable for various types of hypertension, including severe and refractory hypertension. It can be used for a long time in the treatment of refractory congestive heart failure. It is also used in the treatment of primary pulmonary hypertension, diffuse esophageal spasm, bronchial asthma, duodenal ulcer, urethral obstruction, exercise-induced asthma, achalasia, etc.