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CAS:2310299-91-1
Molecular Formula:C20H27N5O11S
CAS:2189684-44-2
Molecular Formula:C39H32ClF10N7O5S2
Alias
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1H-Cyclopropa[3,4]Cyclopenta[1,2]Pyrazole-1-Acetamide,N-[(1S)-1-[3-[4-Chloro-3-[(Methylsulfonyl)Amino]-1-(2,2,2-Trifluoroethyl)-1H-Indazol-7-yl]-6-[3-Methyl-3-(Methylsulfonyl)-1-Butyn-1-yl]-2-Pyridinyl]-2-(3,5-Difluorophenyl)Ethyl]-5,5-Difluoro-3b,4,4a,5-Tetrahydro-3-(Trifluoromethyl)-,(3bS,4aR)-; GS-6207; GS-HIV; GS-CA1; GS-CA2; GS-714207; N-[(1S)-1-[3-[4-Chloro-3-(Methanesulfonamido)-1-(2,2,2-Trifluoroethyl)Indazol-7-yl]-6-(3-Methyl-3-Methylsulfonylbut-1-ynyl)Pyridin-2-yl]-2-(3,5-Difluorophenyl)Ethyl]-2-[(2S,4R)-5,5-Difluoro-9-(Trifluoromethyl)-7,8-Diazatricyclo[4.3.0.02,4]nona-1(6),8-dien-7-yl]Acetamide; N-((S)-1-(3-(4-Chloro-3-(Methylsulfonamido)-1-(2,2,2-Trifluoroethyl)-1H-Indazol-7-yl)-6-(3-Methyl-3-(Methylsulfonyl)but-1-yn-1-yl)Pyridin-2-yl)-2-(3,5-Difluorophenyl)Ethyl)-2-((3bS,4aR)-5,5-Difluoro-3-(Trifluoromethyl)-3b,4,4a,5-Tetrahydro-1H-Cyclopropa[3,4]Cyclopenta[1,2-c]Pyrazol-1-yl)Acetamide; N-[(1S)-1-(3-{4-Chloro-3-[(Methylsulfonyl)Amino]-1-(2,2,2-Trifluoroethyl)-1H-Indazol-7-yl}-6-[3-Methyl-3-(Methylsulfonyl)but-1-yn-1-yl]Pyridin-2-yl)-2-(3,5-Difluorophenyl)Ethyl]-2-[(3bS,4aR)-5,5-Difluoro-3-(Trifluoromethyl)-3b,4,4a,5-Tetrahydro-1H-Cyclopropa[3,4]Cyclopenta[1,2-c]Pyrazol-1-yl]Acetamide; QNG; N-[(1S)-1-[3-[4-Chloro-3-(Methanesulfonamido)-1-(2,2,2-Trifluoroethyl)Indazol-7-yl]-6-(3-Methyl-3-Methylsulfonyl-but-1-ynyl)-2-Pyridyl]-2-(3,5-Difluorophenyl)Ethyl]-2-[Difluoro(Trifluoromethyl)[?]yl]Acetamide
Brief Introduction
Lenacapavir is an HIV-1 capsid inhibitor. In MT-4 cells, gs-6207 has anti HIV activity with an EC50 of 100 PM, and in peripheral blood mononuclear cells, the average EC50 for 23 HIV-1 clinical isolates from different subtypes is 50 PM (20 – 160 PM).
CAS:2097132-94-8
Molecular Formula:C27H32FN9O2
Alias
More Information
BLU-667; Pralsetinib free base; cis-Pralsetinib; Blu667; Trans-Pralsetinib; N-[(1S)-1-[6-(4-Fluoropyrazol-1-yl)Pyridin-3-yl]Ethyl]-1-Methoxy-4-[4-Methyl-6-[(5-Methyl-1H-Pyrazol-3-yl)Amino]Pyrimidin-2-yl]Cyclohexane-1-Carboxamide; cis-N-{(1S)-1-[6-(4-Fluoro-1H-Pyrazol-1-yl)Pyridin-3-yl]Ethyl}-1-Methoxy-4-{4-Methyl-6-[(5-Methyl-1H-Pyrazol-3-yl)Amino]Pyrimidin-2-yl}Cyclohexane-1-Carboxamide; Gavreto; (1s,4R)-N-((S)-1-(6-(4-Fluoro-1H-Pyrazol-1-yl)Pyridin-3-yl)Ethyl)-1-Methoxy-4-(4-Methyl-6-((5-Methyl-1H-Pyrazol-3-yl)Amino)Pyrimidin-2-yl)Cyclohexane-1-Carboxamide; (1r,4S)-N-((S)-1-(6-(4-Fluoro-1H-Pyrazol-1-yl)Pyridin-3-yl)Ethyl)-1-Methoxy-4-(4-Methyl-6-((5-Methyl-1H-Pyrazol-3-yl)Amino)Pyrimidin-2-yl)Cyclohexane-1-Carboxamide
Brief Introduction
Blu667 is a highly effective and selective RET inhibitor with an IC50 value of 0.4 nm for inhibiting wild-type RET kinase.
CAS:58944-73-3
Molecular Formula:C15H23N7O5
Brief Introduction
Sinefungin is an effective inhibitor of viral mRNA (guanine-7 -) - methyltransferase, mRNA (nucleoside - 2 '-) - methyltransferase and viral proliferation. Sinefungin is a SET7/9 inhibitor, which can improve renal fibrosis by inhibiting H3K4 methylation.
CAS:1340593-59-0
Molecular Formula:C23H16F7N5O2
Brief Introduction
Oteseconazole is an oral fungal CYP51 inhibitor, and its selectivity to fungal CYP51 is significantly better than the existing commonly used azole drugs.
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