D13-9001 is a potent AcrB (AcrAB-TolC efflux pump subunit) and MexB (MexAB-OprM efflux pump subunit) inhibitor with the KD values of 1.15 μM and 3.57 μM in E. coli and P. aeruginosa, respectively. D13-9001 exhibits antibiotic activities.

Ebselen

CAS:60940-34-3

Molecular Formula:C13H9NOSe

Alias

More Information

Ebseleno; Ebselene; Harmokisane; 2-Phenyl-1,2-Benzoselenazol-3-one; Ebselenum; 2-Phenylbenzo[d][1,2]Selenazol-3(2H)-one; 2-Phenyl-1,2-Benzisoselenazol-3(2H)-one

Brief Introduction

Ebselen is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimetic and is thereby able to prevent cellular damage induced by reactive oxygen species (ROS). In addition, this agent inhibits the activity of a variety of enzymes including nitric oxide synthase (NOS), 5-lipoxygenase, cyclooxygenase, protein kinase C (PKC), NADPH oxidase and gastric H+/K+-ATPase. Furthermore, ebselen may be neuroprotective due to its ability to neutralize free radicals upon NMDA receptor activation thus, reducing lipoperoxidation mediated by glutamate-induced excitotoxicity.

Odevixibat

CAS:501692-44-0

Molecular Formula:C37H48N4O8S2

Brief Introduction

BYLVAY is an ileal bile acid transporter (IBAT) inhibitor indicated for the treatment of pruritus in patients with progressive familial intrahepatic cholestasis (PFIC) of 3 months and older.

P300/CBP-IN-5

CAS:1889284-33-6

Molecular Formula:C29H27F5N6O4

Alias

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Spiro[Imidazolidine-4,1'-[1H]Indene]-1-Acetamide,3'-Fluoro-N-[(4-Fluorophenyl)Methyl]-2',3'-Dihydro-5'-[1-Chemicalbook[2-(Methylamino)-2-Oxoethyl]-1H-Pyrazol-4-yl]-2,5-Dioxo-N-[(1S)-2,2,2-Trifluoro-1-Methylethyl]-,(1'S,3'R)-; CBP/p300-IN-5; iP300w

Brief Introduction

iP300w is a potent p300/CBP inhibitor. iP300w inhibits p300-mediated H3K9 acetylation (IC50 = 33 nM). The cytotoxicity of DUX4 and overexpression of DUX4 target genes are inhibited by iP300w in vitro. In addition, the compound inhibits DUX4-mediated transcription in an animal model of facioscapulohumeral muscular dystrophy (FSHD). iP300w reduces viability and inhibits proliferation of CIC-DUX4 sarcoma (CDS) cells in vitro but not pancreatic or colorectal cancer cell lines. The compound suppresses tumor growth in a mouse CDS xenograft model.

Avibactam

CAS:1192500-31-4

Molecular Formula:C7H11N3O6S

Alias

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(E)-7-Fluoro-3-Methylhept-4-en-2-one; (2S,5R)-7-Oxo-6-(Sulfooxy)-1,6-Diazabicyclo[3.2.1]Octane-2-Carbox Amide; 4-Hepten-2-one,7-Fluoro-3-Methyl-,(E); Trans-7-Fluoro-3-Methyl-4-Hepten-2-one; Trans-7-oxo-6-(Sulphooxy)-1,6-Diazabicyclo[3.2.1]Octane-2-Carboxamide; Avibactam free acid; NXL104; AVE-1330A free acid

Brief Introduction

Avibactam is a member of the class of azabicycloalkanes that is (2S,5R)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide in which the amino hydrogen at position 6 is replaced by a sulfooxy group. Used (in the form of its sodium salt) in combination with ceftazidime pentahydrate for the treatment of complicated urinary tract infections including pyelonephritis. It has a role as an antibacterial drug, an antimicrobial agent and an EC 3.5.2.6 (beta-lactamase) inhibitor. It is a monocarboxylic acid amide, a member of ureas, an azabicycloalkane and a hydroxylamine O-sulfonic acid. It is a conjugate acid of an avibactam(1-).

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