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CAS:154229-19-3
Molecular Formula:C24H31NO
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(3Beta)-17-(3-Pyridinyl)-Androsta-5,16-Dien-3-Ol; Androsta-5,16-Dien-3-Ol, 17-(3-Pyridinyl)-, (3Beta)-; Cb 7598; Cb-7598; Unii-G819A456D0; Abiraterone(Cb-7598); 17-(3-Pyridyl)Androsta-5,16-Dien-3Beta-Ol; Cb7598; Zytiga
Brief Introduction
Abiraterone acetate (INN, USAN, BAN, JAN) (brand names Zytiga, Abiratas, Abretone, Abirapro) is a steroidal antiandrogen, specifically an androgen synthesis inhibitor, used in combination with prednisone in metastatic castration-resistant prostate cancer (previously called hormone-resistant or hormone-refractory prostate cancer) – i.e., prostate cancer not responding to androgen deprivation or treatment with androgen receptor antagonists. It is a prodrug to the active agent abiraterone, and is marketed by Janssen Biotech under the trade name Zytiga. In addition, Intas Pharmaceuticals markets the drug under the trade name Abiratas, Cadila Pharmaceuticals markets the drug as Abretone, and Glenmark Pharmaceuticals as Abirapro.
Abiraterone acetate was approved by the United States Food and Drug Administration on April 28, 2011. The FDA press release made reference to a phase III clinical trial in which abiraterone use was associated with a median survival of 14.8 months versus 10.9 months with placebo; the study was stopped early because of the successful outcome.
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CAS:154361-50-9
Molecular Formula:C15H22FN3O6
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Pentyl [1-(3,4-Dihydroxy-5-Methyl-Oxolan-2-Yl)-5-Fluoro-2-Oxo-Pyrimidin-4-Yl]Aminoformate; Xeloda; Capecytabine; Ro 09-1978; Captabin; 5'-Deoxy-5-Fluoro-N-[(Pentyloxy)Carbonyl]Cytidine; Ro-9-1978; 5'-Deoxy-5-Fluoro-N4-[(Pentyloxy)Carbonyl]Cytidine; Cpecitabine; Capecitibine; Ro 09-1978/000; Capcitabine; 5'-Deoxy-5-Fluorocytisine; Pentyl (1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-Methyltetrahydrofuran-2-Yl)-5-Fluoro-2-Oxo-1,2-Dihydr
Brief Introduction
Capecitabine, an antimetabolite fluoropyrimidine deoxynucleoside carbamate that can be converted to 5-FU in vivo, was developed by Roche under the trade name hiloda and is able to inhibit cell division and interfere with RNA and protein synthesis. For further treatment of paclitaxel and advanced primary or metastatic breast cancer including patients refractory to chemotherapeutic regimens with anthracyclines. It is mainly used for the treatment of advanced primary or metastatic breast, rectal, colon and gastric cancer.
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CAS:184475-35-2
Molecular Formula:C22H24ClFN4O3
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Iressa; N-(3-Chloro-4-Fluorophenyl)-7-Methoxy-6-(3-Morpholinopropoxy)Quinazolin-4-Amine; Irressat; N-(3-Chloro-4-Fluorophenyl)-7-Methoxy-6-(3-Morpholin-4-Ylpropoxy)Quinazolin-4-Amine
Brief Introduction
Gefitinib is a quinazoline epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. It inhibits the autophosphorylation of tyrosine kinase domain in EGFR cells by competitive binding to ATP and blocks the transmission of downstream signals, so as to inhibit tumor angiogenesis, cell proliferation, invasion and metastasis and promote apoptosis.
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CAS:220127-57-1
Molecular Formula:C30H35N7O4S
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4-[(4-Methyl-1-Piperazinyl)Methyl]-N-[4-Methyl-3-[[4-(3-Pyridinyl)-2-Pyrimidinyl]Amino]Phenyl]-Benzamide Monomethanesulfonate; 4-[(4-Methylpiperazin-1-Yl)Methyl]-N-[4-Methyl-3-[(4-Pyridin-3-Ylpyrimidin-2-Yl)Amino]Phenyl]Benzamide Methanesulfonate
Brief Introduction
This product is an anti-tumor drug.
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CAS:320-67-2
Molecular Formula:C8H12N4O5
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Vidaza; Ladakamycin; 5-Azacitidine; Azacitidine; 5-Ac; 5-Azac; Azgr; 5 Azc; [14C]-Azacitidine; 5-Azcr; 5-Ac-15N4; 5'-Azacytidine; Mylosar; 1,3,5-Triazine-2(1H)-One, 4-Amino-1-α-D-Ribofuranosyl-
Brief Introduction
Antimetabolic drugs. The main indication is acute myeloid leukemia which is ineffective to conventional treatment. It is also used for breast cancer, melanoma, intestinal cancer and so on. The main manifestations of toxicity were leucopenia, thrombocytopenia and anemia. Nausea and vomiting are common adverse reactions. Symptoms can be improved by continuous infusion for a long time, or antiemetic agents can be used 24 to 48 hours before treatment. Other toxic effects were diarrhea, neuromuscular disorders, fever, hypotension and rash. The preparation is freshly prepared 3-4h before use.
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