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Antineoplastic Agents

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CAS:763113-22-0
Molecular Formula:C24H23FN4O3
Phthalazinone; 1-(Cyclopropylcarbonyl)-4-[5-[(3,4-Dihydro-4-Oxo-1-Phthalazinyl)Methyl]-2-; 4-(3-(4-(Cyclopropanecarbonyl)Piperazine-1-Carbonyl)-4-Fluorobenzyl)Phthalazin-1(2H)-One
Brief Introduction
Ola Pani is a chemotherapeutic agent for the treatment of recurrent or advanced ovarian cancer and metastatic breast cancer in patients with specific mutations and previous history of chemotherapy. Olapani is sold under the lynparza brand in the form of oral tablets and was originally designated as maintenance therapy or monotherapy for adult patients with recurrent epithelial ovarian cancer, fallopian tube cancer or primary peritoneal cancer.
CAS:85622-93-1
Molecular Formula:C6H6N6O2
Temodar; 4-Methyl-5-Oxo-2,3,4,6,8-Pentazabicyclo[4.3.0]Nona-2,7,9-Triene-9-Carboxamide; Methazolastone; 3,4-Dihydro-3-Methyl-4-Oxoimidazo[5,1-D]-1,2,3,5-Tetrazin-4(3H)-One; TMZ
Brief Introduction
Temozolomide is the first oral effective imidazo tetrazine antitumor drug. It belongs to the second generation alkylating agent with antitumor activity. It does not need intrahepatic metabolic activation after oral administration. It is characterized by easy penetration through the blood-brain barrier, good tolerance and no superimposed toxicity with other drugs. It has synergistic effect with radiotherapy. It is suitable for malignant gliomas that relapse after routine treatment, For example, glioblastoma multiforme or degenerative astrocytoma is also the first-line drug for the treatment of metastatic melanoma.
CAS:107007-99-8
Molecular Formula:C18H25ClN4O
1-Methyl-N-[(3-Endo)-9-Methyl-9-Azabicyclo[3.3.1]Non-3-Yl]-1H-Indazole-3-Carboxamide; 1-Methyl-N-[(1S,5R)-9-Methyl-9-Azabicyclo[3.3.1]Nonan-3-Yl]Indazole-3-Carboxamide,Hydrochloride; 1-Methyl-N-(9-Methyl-9-Azabicyclo(3.3.1)Non-3-Yl)-1H-Indazole-3-Carboxamid; Endo-Monohydrochlorid; 1-Methylindazole-3-Carboxylic acid; Midehydrochloride; 1-Methyl-N-[(3-Endo)-9-Methyl-9-Azabicyclo[3.3.1]Non-3-Yl]-1H-Indazole-3-Carboxamide Hydrochloride; 1-Methyl-N-(9-Methyl-9-Azabicyclo[3.3.1]Nonan-3-Yl)-1H-Isoindole-3-Carboxamide Hydrochloride
Brief Introduction
Granisetron hydrochloride is a highly selective 5-HT3 receptor antagonist, which has good preventive and therapeutic effects on nausea and vomiting caused by radiotherapy, chemotherapy and surgery. Radiotherapy, chemotherapy and surgery can cause the release of 5-HT from the intestinal chromaffin cells. 5-HT can activate the 5-HT3 receptor of the central or vagus nerve and cause vomiting reflex. The mechanism of controlling nausea and vomiting is to inhibit the occurrence of nausea and vomiting by antagonizing 5-HT3 receptors in central chemosensory area and peripheral vagus nerve endings. It has high selectivity and no side effects such as extrapyramidal reaction and excessive sedation.
CAS:120511-73-1
Molecular Formula:C17H19N5
Ici-D-1033; Zd-1033; Anastrol; 1,3-Benzenediacetonitrile; Anastrazole; 2,2'-(5-((1H-1,2,4-Triazol-1-Yl)Methyl)-1,3-Phenylene)Bis(2-Methylpropanenitrile); 4-Triazol-1-Ylmethyl)-1; Anastrolozole; Anatrozole; Anastrozol; Arimidex; 1-[3,5-Di-(1-Methyl-1-Cyano)-Ethyl]-Benzyl-1,2,4-Triazole; α,α,α’,α'-Tetramethyl-5-(1H-1,2,4-Triazol-1-Ylmethyl)-1,3-Benzenediacetonitrile; 2-[3-(2-Cyanopropan-2-Yl)-5-(1,2,4-Triazol-1-Ylmethyl)Phenyl]-2-Methylpropanenitrile; α1,α1,α3,α3-Tetramethyl-5-(1H-1,2,4-Triazol-1-Ylmethyl)-1,3-Benzenediacetonitrile
Brief Introduction
Anastrozole is a potent selective three azole aromatase inhibitor, which inhibits the cytochrome P-450 dependent aromatase and thus blocks the biosynthesis of estrogen. Estrogen is a major factor in stimulating the growth of breast cancer cells. Letrozole is suitable for postmenopausal women with advanced breast cancer, and is used for second-line treatment after the failure of anti estrogen therapy.
CAS:122111-03-9
Molecular Formula:C9H12ClF2N3O4
2'-Deoxy-2',2'-Difluorocytidine; Gemcitabine Hcl(Tabines); 2’,2’-Difluorodeoxycytidinemonohydrochloride; 2’-Deoxy-2’,2’-Difluorocytidinemonohydrochloride; 2’-Deoxy-2’,2’-Difluoro-Cytidinmonohydrochloride; Gemzar; Ly188011; Ly188011 Hydrochloride; 2',2'-Difluoro-2'-Deoxycytidine
Brief Introduction
Gemcitabine hydrochloride is a synthetic new type of two fluoronucleoside antitumor drug developed by Eli Lilly. It was approved in 1995 in South Africa, Sweden, Holland, Australia and other countries. In 1996, the US Food and Drug Administration approved the first line treatment for non-small cell lung cancer and pancreatic cancer. Gemcitabine hydrochloride, a nucleoside homologue, is a cell cycle specific antitumor drug. It mainly kills cells in S phase (DNA synthesis) and blocks the transition of cell proliferation from G1 to S phase. Gemcitabine is suitable for the treatment of advanced or metastatic pancreatic cancer and locally advanced or metastatic non-small cell lung cancer, advanced and non-small cell lung cancer, pancreatic cancer, bladder cancer, breast cancer and other solid tumors.
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