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CAS:147-94-4
Molecular Formula:C9H13N3O5
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Cytosine β-D-Arabinofuranoside; 4-Amino-1-((2R,3S,4S,5R)-3,4-Dihydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-Yl)Pyrimidin-2(1H)-One; 4-Amino-1-β-D-Arabinofuranosyl-2(1H)-Pyrimidinone; 4-Amino-1-[(2R,3S,4S,5R)-3,4-Dihydroxy-5-(Hydroxymethyl)Oxolan-2-Yl]Pyrimidin-2-One; Cytosine β-D-Arabinofuranosid; Depocyt (Cytarabine); 4-Amino-1-[(2R,3S,4S,5R)-3,4-Dihydroxy-5-(Hydroxymethyl)Oxolan-2-Yl]-1,2-Dihydropyrimidin-2-One; 4-Amino-1-Beta-D-Arabinofuranosyl-2(1H)-Pyrimidinone; Arabinocytidine; Cytosine Beta-D-Arabinofuranoside; Ara-C; Ara-Cell
Brief Introduction
Cytarabine is a kind of purine nucleoside antiviral drug which is extracted from Streptomyces culture medium and synthesized by chemical method. It is slightly soluble in water, and its monophosphate is easily soluble in water. It can inhibit HSV1 and HSV2, hepatitis B virus, varicella zoster virus and cytomegalovirus, but has no effect on smallpox virus, adenovirus, other DNA or RNA viruses, bacteria and fungi. At present, the exact mechanism of cytosine arabinoside antiviral has not been fully elucidated, which is mainly related to the inhibition of virus replication. Drugs and their metabolites block the synthesis of viral DNA by inhibiting viral DNA polymerase, while drugs only penetrate into viral DNA molecules in a very small amount. Cytarabine is also one of the most effective drugs for the treatment of acute non lymphocytic myeloid leukemia in China.
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CAS:150399-23-8
Molecular Formula:C20H19N5Na2O6
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Alimta; L-Glutamic Acid Disodium Salt; N-[4-[2-(2-Amino-4,7-Dihydro-4-Oxo-1H-Pyrrolo[2,3-D]Pyrimidin-5-Yl)Ethyl]Benzoyl]-
Brief Introduction
Pemetrexed disodium is a tumor drug successfully developed by Eli Lilly Pemetrexed disodium is a multi-target antifolate preparation with pyrrolidine pyrimidine group in structure. It is a dual inhibitor of nucleotide synthase enzyme / dihydrofolate reductase. It can inhibit cell replication by destroying the normal folate dependent metabolism process in cells, and block three different enzyme targets that are crucial to the survival of cancer cells at the same time, So as to inhibit the growth of tumor.
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CAS:4291-63-8
Molecular Formula:C10H12ClN5O3
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2-Chloro-2'-Deoxyadenosine; 2-Cda; 2Cda; 2-Chloro-2′-Deoxyadenosine; 2-Chloro-9-(2-Deoxy-β-D-Arabinofuranosyl)Adenine; 2-Cl-Dado; Cda; Cladrivine
Brief Introduction
Cladribine is a purine analogue and antineoplastic agent used primarily in the therapy of hairy cell leukemia. Cladribine is typically given intravenously daily for 7 days, usually as a single course, and has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent acute liver injury with jaundice.
Cladribine is 2'-Deoxyadenosine in which the hydrogen at position 2 on the purine ring has been substituted by chlorine. It inhibits the synthesis and repair of DNA, particularly in lymphocytes and monocytes, and is used as an antimetabolite antineoplastic drug for the treatment of lymphoid malignancies including hairy-cell leukaemia and chronic lymphocytic leukaemia. It has a role as an antineoplastic agent and an immunosuppressive agent. It is a purine 2'-deoxyribonucleoside and an organochlorine compound.
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Mitomycin C; ((1As,8S,8Ar,8Bs)-6-Amino-8A-Methoxy-5-Methyl-4,7-Dioxo-1,1A,2,4,7,8,8A,8B-Octahydroazirino[2',3':3,4]Pyrrolo[1,2-A]Indol-8-Yl)Methyl Carbamate; Ametycine; Mitomycin C(Ametycine)
Brief Introduction
Mitomycin is a methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus and other Streptomyces bacterial species. Bioreduced mitomycin C generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis. Preferentially toxic to hypoxic cells, mitomycin C also inhibits RNA and protein synthesis at high concentrations.
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CAS:51-20-7
Molecular Formula:C4H3BrN2O2
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5-Br-Uracil; 5-Bromo-Uraci; 5-Brura; 5-Bromo-2,4-Dioxopyrimidine; 5-Bromo-2,4(1H,3H)-Pyrimidinedione; 5-Bromo-2,4-Dihydroxypyrimidine; 5-Bromo-2,3-Dihydroxypyrimidine; 5-Bromo-1H-Pyrimidine-2,4-Dione
Brief Introduction
5-Bromouracill is a pyrimidine analogue, which is mainly used in the treatment of tumors. 5-fluorouracil is one of the antimetabolic drugs. Xenon difluoride reacts with uracil to produce 5-fluorouracil.
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