Pharmaceutical Raw Materials

Phenoxymethylpenicillin is a narrow spectrum antibiotic also commonly referred to as Penicillin V or Penicillin VK. It is a phenoxymethyl analog of Penicillin G, or [benzylpenicillin]. An orally active naturally penicillin, phenoxymethylpenicillin is used to treat mild to moderate infections in the respiratory tract, skin, and soft tissues caused by penicillin G­-sensitive microorganisms. Phenoxymethylpenicillin has also be used in some cases as prophylaxis against susceptible organisms. While there have been no controlled clinical efficacy studies that were conducted, phenoxymethylpenicillin has been suggested by the American Heart Association and the American Dental Association for use as an oral regimen for prophylaxis against bacterial endocarditis in patients with congenital heart disease or rheumatic or other acquired valvular heart disease when they undergo dental procedures and surgical procedures of the upper respiratory tract, except for those who are at an elevated risk for endocarditis.

Dabigatran etexilate mesylate is a direct thrombin inhibitor used in clinical practice and is a new type of oral anticoagulant. Its mechanism of action is to inhibit thrombus formation by reversibly and potently competing for the specific binding site of fibrin that binds thrombin, thereby blocking fibrin generation.

This product is used as medicine raw material.

Nevirapine is a non nucleoside reverse transcriptase inhibitor, which blocks RNA dependent and DNA dependent DNA polymerase activity by directly connecting with HIV-1 reverse transcriptase (RT) and breaking the catalytic end of the enzyme. It does not compete with substrate or nucleoside triphosphate, and can be combined with other antiretroviral drugs to treat HIV-1 infection. In June 1996, it was approved by the U.S. Food and Drug Administration (FDA) to treat adult HIV infection with nucleoside drugs. At present, common adverse reactions include skin rash, abnormal liver function, fatigue, fever, headache, drowsiness, gastrointestinal adverse reactions and myalgia. Severe liver injury, liver failure and allergic reaction. In January 2005, FDA released a message on its official website to remind medical staff that patients with high CD4 cell count (male > 400 / mm3, female > 250 / mm3) have a higher risk of liver injury. Therefore, for patients who have not received antiviral therapy before, if the CD4 cell count is higher than the above two limits, nevirapine should be avoided.

As a new pharmaceutical excipient, beta cyclodextrin is mainly used to increase the stability of drugs, prevent drug oxidation and decomposition, improve the solubility and bioavailability of drugs, reduce the toxicity and side effects of drugs, and cover up the peculiar smell and odor of drugs. In food manufacturing, it is mainly used to eliminate odor and odor, improve the stability of spices, flavors and pigments, enhance the emulsifying capacity and moisture resistance, and improve the taste of food. It is a good stabilizer, emulsifier and flavoring agent in the manufacturing of drugs, food and cosmetics.