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1-(4-Methoxyphenyl)-7-Oxo-6-[4-(2-Oxopiperidin-1-Yl)Phenyl]-4,5-Dihydropyrazolo[3,4-C]Pyridine-3-Carboxamide; Eliquis; Unii-3Z9Y7Uwc1J; Bms-562247-01; Bms-562247
Brief Introduction
Apixaban (inn, trade name eliquis) is an anticoagulant used to prevent venous thromboembolism and atrial fibrillation stroke. It is a direct factor Xa inhibitor. Apixaban has been listed in Europe since May 2011. The drug was developed by a joint venture between Pfizer and Bristol Myers Squibb.
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CAS:571190-30-2
Molecular Formula:C24H29N7O2
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Ibrance(Trade name); Pabcilib; Pabosi Ni
Brief Introduction
Pabcicilib is an inhibitor of cyclin dependent kinase (CDK) 4 and 6. Cyclin D1 and CDK4 / 6 are downstream signaling pathways leading to cell proliferation. In vitro, the proliferation of ER positive breast cancer cells was inhibited by blocking the progression from G1 to S phase. Compared with the treatment of each drug alone, the combination of pabacib and anti estrogen resulted in decreased phosphorylation of retinoblastoma protein (RB), decreased E2F expression and signal, and prevented growth. In vitro treatment of ER positive breast cancer cell lines with combination of pabacib and anti estrogen resulted in increased cell senescence, which lasted up to 6 days after drug removal.
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CAS:857890-39-2
Molecular Formula:C22H23ClN4O7S
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4-(3-Chloro-4-(Cyclopropylaminocarbonyl)Aminophenoxy)-7-Methoxy-6-Quinolinecarboxamide Methanesulfonate; E7080 Mesylate; UNII-3J78384F61; Lenvatinib Mesilate (JAN)
Brief Introduction
Lovatinib mesylate is the mesylate of lovatinib. Lovatinib is a multi-target tyrosine kinase inhibitor developed by Japan Weicai company. It has a novel binding mode. In addition to inhibiting other tyrosine kinases related to angiogenesis and carcinogenic signal pathways involved in tumor proliferation, It can also selectively inhibit the kinase activity of vascular endothelial growth factor (VEGF) receptor, such as VEGF-1, VEGF-2 and vegf-3.
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CAS:1231929-97-7
Molecular Formula:C27H32F2N8
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N-(5-((4-Ethylpiperazin-1-yl)Methyl)Pyridin-2-yl)-5-Fluoro-4-(4-Fluoro-1-Isopropyl-2-Methyl-1H-Benzo[d]Imidazol-6-yl)Pyrimidin-2-Amine
Brief Introduction
Abemaciclib is an oral cyclin dependent kinase CDK4 / 6 inhibitor
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Tablets；50mg/100mg/150mg/200mg，class 4 drug
/
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CAS:917389-32-3
Molecular Formula:C29H28F4N4O4
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AIC246; CS-2799; MK-8828; UNII-1H09Y5WO1F; (4S)-8-Fluoro-3,4-Dihydro-2-[4-(3-Methoxyphenyl)-1-Piperazinyl]-3-[2-Methoxy-5-(Trifluoromethyl)Phenyl]-4-Quinazolineacetic acid; -Quinazolineacetic acid, 8-Fluoro-3,4-Dihydro-2-[4-(3-Methoxyphenyl)-1-Piperazinyl]-3-[2-Methoxy-5-(Trifluoromethyl)Phenyl]-, (4S)-
Brief Introduction
Letimovir is a novel anti CMV compound, which targets the virus terminal enzyme complex. Viruses resistant to DNA polymerase inhibitors also have activity.
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