Hormones and Endocrine Drugs

Oxytocin, also known as oxytocin, is a uterine contractile drug, which can be extracted from the posterior pituitary of animals or chemically synthesized. The chemical synthetic product does not contain vasopressin, has no pressor effect, has selective excitation effect on uterine smooth muscle, and strengthens its contraction. The parturient uterus is the most sensitive to oxytocin (increased estrogen secretion), the immature uterus is not reactive to this product, and the uterus in the early or middle trimester of pregnancy has low reactivity to oxytocin, It gradually increased in the late pregnancy and reached the highest before labor. A small dose can strengthen the rhythmic contraction of the smooth muscle at the bottom of the uterus, strengthen its contractility, accelerate the contraction frequency, and maintain the polarity and symmetry similar to natural delivery. Therefore, it is clinically used for inducing labor. Large doses make the uterine muscles contract in a tetanic manner, which is clinically used to compress the blood vessels between muscle fibers, prevent postpartum hemorrhage and postpartum incomplete involution, and promote lactation, shrink the mammary duct, and promote the excretion of milk from the breast, but can not increase the secretion of milk, but can only promote the excretion of milk. It should be noted that the dosage and dropping speed should be strictly controlled when it is used to induce labor or labor, so as not to cause ankylosing uterine contraction, fetal asphyxia or uterine rupture. It is forbidden when there is cephalopelvic disproportion, fetal position or other birth canal abnormalities, uterine contraction is poor, there is a history of cesarean section and more than 3 times of maternity.

Methyltestosterone mainly promotes the development and maturation of male reproductive organs, develops and maintains the secondary sexual characteristics, and enables boars to show male behavior. High dose injection can inhibit the secretion of gonadotropin in the anterior pituitary and fight against estrogen. It also has a significant effect on promoting protein synthesis, which can reduce the protein breakdown in vivo, increase nitrogen and inorganic salts retention in the body, make muscles develop * and accelerate body weight. A large dose can stimulate the hematopoietic function of bone marrow and promote the production of red blood cells. It is used to treat sexual desire deficiency, trauma, fracture, aplastic anemia or other causes of boars.

Cloxotestosterone acetate is an androgen drug.

Insulin glargine is a recombinant human insulin analogue, which has the characteristics of stability, no peak, long action time and so on. It has low solubility in neutral solution and can be completely dissolved in acidic solution (pH 4). After subcutaneous injection, because the acidic solution is neutralized to form fine deposits, a small amount of insulin glargine can be continuously released, resulting in a predictable blood concentration with no peak for up to 24 hours. The biological potency of this product is the same as that of human insulin.