Colistimethate Sodium is a polypeptide antibiotic composed of many components, mainly composed of E1 and E2 (or a or b). In the 1950s, polymyxin E was used in clinic, mainly for the treatment of infections caused by gram-negative bacteria, especially those caused by multidrug-resistant Pseudomonas aeruginosa.

Oritavancin

CAS:171099-57-3

Molecular Formula:C86H97Cl3N10O26

Brief Introduction

The FDA has approved the antibiotic Orbactiv (oritavancin, oritavancin, IV) injection for acute bacterial skin and skin structure infections caused by sensitive Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus, MRSA (ABSSSIs) in the treatment of adult patients.

2,8-Diazabicyclo[4.3.0]Nonane

CAS:151213-40-0

Molecular Formula:C7H16Cl2N2

Alias

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(4aS,7aS)-Octahydro-1H-Pyrrolo[3,4-b]Pyridine; (1S,6S)-2,8-Diazabicyclo[4.3.0]Nonane

Brief Introduction

It is the important intermediate of Moxifloxacin

Cefiderocol

CAS:1225208-94-5

Molecular Formula:C30H34ClN7O10S2

Alias

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(6R,7R)-7-[[(2Z)-2-(2-Amino-1,3-Thiazol-4-yl)-2-(2-Carboxypropan-2-Yloxyimino)Acetyl]Amino]-3-[[1-[2-[(2-Chloro-3,4-Dihydroxybenzoyl)Amino]Ethyl]Pyrrolidin-1-ium-1-yl]Methyl]-8-oxo-5-thia-1-Azabicyclo[4.2.0]oct-2-ene-2-Carboxylate; S-649266; RSC 649266

Brief Introduction

Cefiderocol is a new type of iron carrier cephalosporin, which has strong broad-spectrum activity against aerobic gram-negative bacteria.

Lefamulin

CAS:1061337-51-6

Molecular Formula:C28H45NO5S

Alias

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BC-3781; Xenleta; (3aR,4R,5R,7S,8S,9R,9aS,12R)-8-Hydroxy-4,7,9,12-Tetramethyl-3-oxo-7-Vinyldecahydro-4,9a-Propanocyclopenta[8]Annulen-5-yl 2-(((1R,2R,4R)-4-Amino-2-Hydroxycyclohexyl)thio)Acetate; (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-Ethenyl-5-Hydroxy-4,6,9,10-Tetramethyl-1-Oxodecahydro-3a,9-Propanocyclopenta[8]Annulen-8-yl {[(1R,2R,4R)-4-Amino-2-Hydroxycyclohexyl]Sulfanyl}Acetate; [(1S,2R,3S,4S,6R,7R,8R,14R)-4-Ethenyl-3-Hydroxy-2,4,7,14-Tetramethyl-9-oxo-6-Tricyclo[5.4.3.01,8]Tetradecanyl] 2-[(1R,2R,4R)-4-Amino-2-Hydroxycyclohexyl]Sulfanylacetate; 14-O-{[(1R,2R,4R)-4-Amino-2-Hydroxy-Cyclohexylsulfanyl]-Acetyl}-Mutilin

Brief Introduction

Lefamulin is an oral active antibiotic.

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