(+/-)-Methoxyverapamil,Hydrochloride; Gallopamil Hydrochloride; D 600 Hydrochloride; D600,Hcl; (+/-)-Methoxyverapamil Hcl; Gallopamil Hcl; Gallopamil; D600; (S)-Gallopamil; Procorum

Brief Introduction

Gallopamilhydrochloride is a methoxy derivative of verapamil and a phenylalkylamine calcium antagonist. Gallopamilhydrochloride inhibited acid secretion in a concentration dependent manner with an IC50 of 10.9 μ M。 Gallopamilhydrochloride is an effective antiarrhythmic and vasodilator.

Anidulafungin

CAS:166663-25-8

Molecular Formula:C58H73N7O17

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V-Echinocandin; Anidulafungin; Ver-002; Ecalta; Eraxis; Unii-9Hlm53094I

Brief Introduction

Anifenjing is an echinocandin antifungal drug, and its mechanism of action is the same as "caspofungin". It has antibacterial activity against Candida and Aspergillus, but not against Cryptococcus, Fusarium and trichosporum.

(4S,7S,10As)-5-Oxo-4-[[(2S)-3-Phenyl-2-Sulfanylpropanoyl]Amino]-2,3,4,7,8,9,10,10A-Octahydropyrido[2,1-B][1,3]Thiazepine-7-Carboxylic Acid

CAS:167305-00-2

Molecular Formula:C19H24N2O4S2

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Omapatrilat; Omapatrilat (Jan/Usan/Inn); Vanlev; Bms-186716; Bms 186716

Brief Introduction

Omapatrilat (INN) is a novel antihypertensive agent that inhibits both neutral endopeptidase (NEP) and angiotensin converting enzyme. NEP inhibition results in elevated natriuretic peptide levels, promoting natriuresis, diuresis, vasodilation, and reductions in preload and ventricular remodeling. This drug from Bristol-Myers Squibb was not approved by the U.S. Food and Drug Administration due to angioedema safety concerns. Omapatrilat angioedema was attributed to its dual mechanism of action, inhibiting both angiotensin converting enzyme (ACE), and neutral endopeptidase, both of these enzymes are responsible for the metabolism of bradykinin which causes vasodilation, angioedema, and airway obstruction.

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