Pharmaceutical Intermediates

Triphoto gas (BTC), namely, bis (Trichloromethyl) carbonate, is commonly known as solid phosgene, and the chemical formula is c3cl6o3. It is colorless crystal, has the smell of light gas, mainly used as a substitute for phosgene, and is used in medicine, pesticide and organic synthesis, and has better effect than liquid double light gas. The trioptical gas is prepared by the reaction of dimethyl carbonate and chlorine gas. Three light gas at 130 ° C is decomposed around, and the presence of impurities reduces the temperature. There will also be a small amount of decomposition during atmospheric distillation to generate phosgene and double phosgene (Trichloromethyl chloroformate). When chloride exists, the phosgene can produce phosgene safely and quantitatively, which solves the problem that phosgene can not be quantified in the reaction. Triphosgene can produce almost all reactions of phosgene, and can be used as reagents for chloroformylation, chlorination, carbonylation and some polymerization reactions. It can convert primary amine into isocyanate or substituted urea, carboxylic acid into acyl chloride, alcohol into carbonate or aldehyde (with dimethyl sulfate), aldehyde oxime and amide into nitrile, etc.

Irutinib intermediate N-2 is a useful intermediate for the synthesis of irutinib; A highly selective irreversible inhibitor of Bruton tyrosine kinase (Btk).

O-fluoroaniline is a light yellow liquid, oily; When the amount is small, the color is not obvious. Slightly aromatic, toxic. It can stimulate the skin, and its vapor or smoke can stimulate the eyes, mucous membrane and upper respiratory tract. Enter the human body, can form methemoglobin cyanosis, harmful to the environment, this product is flammable, irritating. O-fluoroaniline is an important intermediate in the synthesis of fluorinated pharmaceuticals and dyes. O-fluoroaniline can be used as an intermediate in pharmaceutical synthesis.

Parafluorotoluene is an important raw material for organic fluorine compounds, used in the synthesis of various pharmaceuticals, pesticides, dyes, polymer fluoroplastic intermediates and fluorine-containing aromatic derivatives.

As a fine intermediate, it is widely used in the synthesis of fluorine-containing pesticides, pharmaceuticals and organic intermediates.