API & Intermediate

Caffeine is a xanthine alkaloid compound and a central nervous stimulant. It can temporarily drive away drowsiness and restore energy. It is clinically used to treat neurasthenia and coma recovery. Coffee, tea, soft drinks and energy drinks with caffeine are very popular. Therefore, caffeine is also the most widely used psychotropic drug in the world.

Pyrimethamine is a broad-spectrum veterinary drug widely used for antigen insects. In addition, pyrimethamine is also used in aquaculture, which can enhance the disease resistance of aquatic fish. However, the side effects of pyrimethamine are serious, excessive use can damage the reproductive system of livestock and poultry, and is not easy to recover. Pyrimethamine can inhibit the primary infrared phase of some falciparum malaria and vivax malaria, so it is a better preventive drug. Although it has no obvious effect on the gametophyte of Plasmodium, the development of Gametophyte in mosquitoes can be affected after the blood containing the drug enters the mosquitoes, so the transmission can be blocked. The principle of action is to inhibit dihydrofolate reductase, affect the utilization of tetrahydrofolate, reduce the synthesis of nucleic acid and inhibit the reproduction of Plasmodium. At the same time, pyrimidine and chloroquine can protect the placental pathological changes after malaria infection by reducing the levels of oxidative stress and apoptosis, and can also effectively reduce the proportion of infected red blood cells in the blood, so as to achieve a good effect of malaria treatment. Moreover, it has enrichment effect in aquatic products, beyond a certain range, it will cause hemolytic anemia after human consumption, and even has direct toxicity to the central nervous system.

Dipyridamole is a pyrimidopyrimidine that is 2,2',2'',2'''-(pyrimido[5,4-d]pyrimidine-2,6-diyldinitrilo)tetraethanol substituted by piperidin-1-yl groups at positions 4 and 8 respectively. A vasodilator agent, it inhibits the formation of blood clots. It has a role as an adenosine phosphodiesterase inhibitor, an EC 3.5.4.4 (adenosine deaminase) inhibitor, a platelet aggregation inhibitor and a vasodilator agent. It is a member of piperidines, a pyrimidopyrimidine, a tertiary amino compound and a tetrol.

Promethazine hydrochloride is the first phenothiazine based tricyclic antihistamine with antitussive effect. It can competitively block histamine H1 receptor to produce antihistamine effect, resist histamine induced telangiectasia, and reduce its permeability. Therefore, it can relieve the cough caused by the stimulation of the trachea.It is suitable for various allergic diseases and vomiting during pregnancy.

As a feed additive, it is mainly used in poultry and sow feed. It can be used as nutrition supplement and food fortifier. It can be used to label proteins, antigens, antibodies, nucleic acids (DNA, RNA), etc.