API & Intermediate

Posaconazole is used in patients with invasive aspergillosis refractory to amphotericin B or itraconazole or in patients who cannot tolerate treatment with these agents.It is clinically useful in the treatment of aspergillosis, zygomycosis and sickle cell disease, but also in the treatment of some fluconazole resistant Candida infections.

Endo Cave hydrate is a new type of cyclopentylguanosine anti HBV drug. Its pharmacological action is similar to that of entredo Cave. It is clinically suitable for the treatment of chronic hepatitis B with active viral replication, elevated serum aminotransferase ALT or liver histology showing active lesions. This product is guanine nucleoside analogue and has inhibitory effect on hepatitis B virus (HBV) polymerase.

Nifedipine is a dihydropyridine calcium antagonist, which can inhibit the Ca2 + uptake of myocardium and vascular smooth muscle, dilate coronary artery, increase coronary blood flow, improve myocardial tolerance to ischemia, dilate peripheral small arteries, reduce peripheral vascular resistance, relieve coronary artery spasm, increase coronary blood flow, improve myocardial hypoxia, and reduce blood pressure. Low dose coronary artery dilation does not affect blood pressure, so it is a good anti angina drug. For the prevention and treatment of angina pectoris of coronary heart disease, it has no adverse effect on respiratory function, especially for angina pectoris caused by coronary artery spasm and angina pectoris with respiratory obstructive disease, the effect is the best, and its curative effect is better than that of traditional Chinese medicine β Receptor blockers. It is also suitable for various types of hypertension, including severe and refractory hypertension. It can be used for a long time in the treatment of refractory congestive heart failure. It is also used in the treatment of primary pulmonary hypertension, diffuse esophageal spasm, bronchial asthma, duodenal ulcer, urethral obstruction, exercise-induced asthma, achalasia, etc.

L-ascorbic acid 2-phosphate is a long-acting vitamin C derivative C It can stimulate the expression and formation of collagen. L-ascorbic acid 2-phosphate can be used as a culture medium to supplement the osteogenic differentiation of human adipose stem cells (hASCs). L-ascorbic acid 2-phosphate increased alkaline phosphatase (ALP) activity and runx2a expression in Hasc during osteoblast differentiation.

2,3-dichloropyridine is used as a reagent for preparing substituted 3 - (5-membered heterocyclic carboxyamido) pyridine derivatives for the treatment of autoimmune diseases and inflammatory diseases. The synthesis, crystal structure and biological activity of a new o-aminobenzamide dicarbonamide insecticide were also synthesized in propargyl ether. Chemical properties white powder