API & Intermediate

In addition to being used as an anthelmintic, levamisole hydrochloride also has immunomodulatory effect, which can effectively improve the immune function of patients. Levamisole can regulate the immune function, mainly on T lymphocytes, to induce the early differentiation and maturation of T cells into functional T cells, so as to promote the normal function of T cells. It can also strengthen the phagocytosis and chemotaxis of macrophages, so as to improve the activity of natural killer cells, produce endogenous interferon, improve the immune function and make it normal, and effectively prevent the progress of pneumonia, Improve cough, lung sounds and other symptoms. In addition, after the immune function of children is weakened, levamisole hydrochloride can increase the content of total complement in blood, especially the production of IgG and IgA, so as to improve the immune effect of respiratory tract Ru membrane, and play the role of virus resistance and anti bacterial infection. Levamisole can not only regulate the immune function, but also restore the immune function. It can show two-way regulation for the abnormal humoral immune function, make it tend to normal development, and help the low cellular immune function return to normal.

3-Fluorobenzoyl chloride can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly in laboratory R & D process and chemical production process. Also used as dyes, pesticides, pharmaceutical intermediates.

Posaconazole is used in patients with invasive aspergillosis refractory to amphotericin B or itraconazole or in patients who cannot tolerate treatment with these agents.It is clinically useful in the treatment of aspergillosis, zygomycosis and sickle cell disease, but also in the treatment of some fluconazole resistant Candida infections.

Endo Cave hydrate is a new type of cyclopentylguanosine anti HBV drug. Its pharmacological action is similar to that of entredo Cave. It is clinically suitable for the treatment of chronic hepatitis B with active viral replication, elevated serum aminotransferase ALT or liver histology showing active lesions. This product is guanine nucleoside analogue and has inhibitory effect on hepatitis B virus (HBV) polymerase.

Nifedipine is a dihydropyridine calcium antagonist, which can inhibit the Ca2 + uptake of myocardium and vascular smooth muscle, dilate coronary artery, increase coronary blood flow, improve myocardial tolerance to ischemia, dilate peripheral small arteries, reduce peripheral vascular resistance, relieve coronary artery spasm, increase coronary blood flow, improve myocardial hypoxia, and reduce blood pressure. Low dose coronary artery dilation does not affect blood pressure, so it is a good anti angina drug. For the prevention and treatment of angina pectoris of coronary heart disease, it has no adverse effect on respiratory function, especially for angina pectoris caused by coronary artery spasm and angina pectoris with respiratory obstructive disease, the effect is the best, and its curative effect is better than that of traditional Chinese medicine β Receptor blockers. It is also suitable for various types of hypertension, including severe and refractory hypertension. It can be used for a long time in the treatment of refractory congestive heart failure. It is also used in the treatment of primary pulmonary hypertension, diffuse esophageal spasm, bronchial asthma, duodenal ulcer, urethral obstruction, exercise-induced asthma, achalasia, etc.