Veterinary API

Since probenecid is almost insoluble in water, when combined with penicillins for injection to form a compound injection, probenecid needs to be transformed into water-soluble salts, usually into water-soluble probenecid sodium. Probenecid sodium and probenecid potassium and β- The compound injection composed of lactam antibiotics and its application can reduce the content in the compound β- The dosage of lactam antibiotics can effectively reduce the occurrence and development of bacterial drug resistance caused by ultra-high dose antibiotics; It can also save antibiotic resources and reduce the abuse of antibiotics; Probenecid sodium (potassium) and β- Lactam antibiotics include penicillin antibiotics and cephalosporin antibiotics, which are composed of powder injection K and lyophilized powder injection β- Lactam antibiotics were injected intravenously or intravenously at the same time. Can effectively extend β- The half-life (T1 / 2) of lactam antibiotics can increase the area under the curve (AUC), eliminate the hemolysis of probenecid sodium (potassium), protect the safety of probenecid sodium (potassium) in human body, and can enter human body safely and effectively as a new compound preparation through intravenous route; By probenecid sodium (potassium) and β- Because the compound injection composed of lactam antibiotics directly enters the blood circulation and is completely absorbed by the human body, it can quickly reach the peak, act quickly and have more remarkable curative effect.

Alfaxalone (INN, JAN), also known as alphaxalone or alphaxolone (BAN), is a neuroactive steroid and general anaesthetic. It is used in veterinary practice under the trade name Alfaxan, and is licensed for use in both dogs and cats. Along with alfadolone, it is also one of the constituents of anesthetic drug mixture althesin. Unlike some of its predecessors alfaxalone is not associated with histamine release and anaphylaxis.; A study 1987 found the primary mechanism for the anaesthetic action of alfaxalone to be modulation of neuronal cell membrane chloride ion transport, induced by binding of alfaxalone to GABAA cell surface receptors. A 1994 study found that alfaxalone binds to a different region of this receptor than the benzodiazepines. These benzodiazepine-insensitive GABAA receptors are located extrasynaptically and are responsible for tonic inhibition. The occurrence of tonic GABAA inhibition coincides with the expression of relatively rare receptor subunits, particularly the α4, α6, and δ subunits, and as a rule of thumb, δ subunit-containing receptors are extrasynaptic. Alfaxalone is metabolised rapidly in the liver. It has a very short plasma elimination half-life in dogs and cats.

Acetylspiramycin is a large lactone semi synthetic oral antibiotic, which is mainly used for the treatment of respiratory infection, pyoderma, erysipelas, scarlet fever, pharyngitis, tonsillitis and otitis media caused by Staphylococcus aureus, hemolytic streptococcus, grass green Streptococcus, pneumococcus, Staphylococcus epidermidis and other bacteria.

Amoxicillin, also known as amoxicillin or amoxicillin, is a widely used oral antibiotic β- Lactam antibiotics, with bacteriolytic effect, mainly for bacterial infections caused by susceptible microorganisms. This product is the first-line drug for the treatment of otitis media. It can also be used for the treatment of streptococcal pharyngitis, pneumonia, honeycomb histitis, urinary tract infection and other symptoms. Common side effects include nausea and rash, and may increase the risk of candidiasis; If combined with clavulanic acid, there are side effects of diarrhea. For those allergic to penicillin, do not use drugs; Patients with renal failure can take this product, but the dosage should be reduced. Taking medicine during pregnancy and lactation does not show any harm at present. Amoxicillin was launched in 1972. Listed in the World Health Organization standard list of essential medicines, it is one of the essential medicines in the basic public health care system, and is also the most commonly used antibiotic for children. Amoxicillin belongs to the scientific name medicine. The wholesale price of each drug is between us $0.02 and US $0.05. In the United States, a 10 day course costs about $16.

Imipene is a veterinary medicinal chemical. It is a diphenylurea benzamidine derivative of pear shaped insect. It is an important compound with biological activity. They have the advantages of broad spectrum, low toxicity, wide application range, long action time and small dosage. They not only have a good therapeutic effect on piroplasmosis, plasmosis and eperythrozoonosis in pigs and dogs, but also have a good preventive effect.