Pharmaceutical Raw Materials

Ethylketazocine (WIN-35,197-2), also known as ethylketocyclazocine (EKC), is an opioid drug of the benzomorphan family which has been used extensively in scientific research in the last few decades as a tool to aid in the study of the κ-opioid receptor. However, due to its relatively poor selectivity for the κ-opioid receptor over the μ- and δ-opioid receptors (of which it has approximately 80% and 20% of the affinity for, respectively, in comparison), as well as its relatively poor intrinsic activity at all sites (i.e., acts as a partial agonist with mixed agonist and antagonist properties), it has been mostly replaced in recent times by newer and more potent and selective compounds like U-50,488 and ICI-199,441.

Dimemorfan is a morphinane alkaloid.

Chlorotoluene thiazide, also known as diazoxide, tachypropin and antihypertensive azine, is a kind of antihypertensive drug. It has the basic structure of thiazide diuretics, but has no diuretic effect. Direct dilation of arterioles has no obvious effect on veins. It may activate ATP sensitive potassium channel to hyperpolarize arterial smooth muscle cells, produce smooth muscle relaxation, reduce peripheral vascular resistance and reduce blood pressure. While lowering blood pressure, the heart rate increases and the cardiac output does not decrease. But the decrease of blood pressure can reflex sympathetic excitement, resulting in tachycardia, myocardial contractility and cardiac output. * it partly counteracts the antihypertensive effect of drugs, and can aggravate the burden of the heart, induce or increase angina pectoris, and increase renin secretion, resulting in an increase in secretion of aldosterone, resulting in retention of water and sodium. B receptor blockers and diuretics can be combined to correct. It is suitable for the first aid of hypertensive crisis, as well as for raising blood sugar, childhood idiopathic hypoglycemia and severe hypoglycemia caused by islet cell tumor.

Carnosic acid is suitable for antioxidation of oil soluble components. It is used in sauces, pet food and feed. It has the effects of antioxidation, anti-aging, weight loss and lipid reduction. It can be used in the treatment of cardiovascular disease and cancer.

Penbutolol (Levatol, Levatolol, Lobeta, Paginol, Hostabloc, Betapressin) is a medication in the class of beta blockers, used in the treatment of high blood pressure. Penbutolol is able to bind to both beta-1 adrenergic receptors and beta-2 adrenergic receptors (the two subtypes), thus making it a non-selective β blocker.:Table 10-2, p 252 Penbutolol is a sympathomimetic drug with properties allowing it to act as a partial agonist at β adrenergic receptors. It was approved by the FDA in 1987 and was withdrawn from the US market by January 2015.