Pharmaceutical Raw Materials

Polyhexanide (polyhexamethylene biguanide, PHMB) is a polymer used as a disinfectant and antiseptic. In dermatological use, it is spelled polihexanide (INN) and sold under names such as Lavasept, Serasept, and Omnicide. PHMB has been shown to be effective against Pseudomonas aeruginosa, Staphylococcus aureus (also the methicillin-resistant type, MRSA), Escherichia coli, Candida albicans (yeast), Aspergillus brasiliensis (mold), vancomycin-resistant enterococci, and Klebsiella pneumoniae (carbapenem-resistant enterobacteriaceae). Some products containing PHMB are used for inter-operative irrigation, pre- and post-surgery skin and mucous membrane disinfection, post-operative dressings, surgical and non-surgical wound dressings, surgical bath/hydrotherapy, chronic wounds like diabetic foot ulcer and burn wound management, routine antisepsis during minor incisions, catheterization, scopy, first aid, surface disinfection, and linen disinfection. PHMB eye drops have been used as a treatment for eyes affected by Acanthamoeba keratitis. Branded as Baquacil, it also has an application as a swimming-pool and spa water sanitizer in place of chlorine- or bromine-based products. It is available as Baqua-Spa 3 sanitize, as Revacil Spa 3 sanitizer, and in the Leisure Time Free system. PHMB is also used as an ingredient in some contact lens cleaning products, cosmetics, personal deodorants and some veterinary products. The PHMB hydrochloride salt (solution) is used in the majority of formulations.

Lovastatin, also known as rosuvastatin, is a fully synthetic drug with high liver selectivity β- Hydroxyl- β- Methylvaleryl CoA reductase inhibitors can significantly reduce the content of serum cholesterol by inhibiting the synthesis of endogenous cholesterol. At the same time, they can also reduce the levels of low-density lipoprotein cholesterol (LDL-C), total cholesterol and apolipoprotein (apo) B, increase the level of high-density lipoprotein cholesterol (HDL-C), and have anti atherosclerotic effect, It is effective for various types of dyslipidemia such as primary hypercholesterolemia and mixed hypercholesterolemia, with good tolerance and mild adverse reactions.

This product has the functions of relieving cough, expectorant, antiasthmatic, antispasmodic, sedative, antiepileptic, reducing blood lipid and promoting lipid. It has different degrees of inhibitory effect on the growth of Diplococcus pneumoniae, Staphylococcus aureus and Escherichia coli, and has certain anticancer activity.

Netupitant is an antiemitic drug. In the United States, the combination drug netupitant/palonosetron (trade name Akynzeo) is approved by the Food and Drug Administration for prevention of acute and delayed chemotherapy-induced nausea and vomiting, including highly emetogenic chemotherapy such as with cisplatin. In Europe, it is approved by the European Medicines Agency for the same indication.

Meseclazone (W2395; Nsc297623) is a non steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic activities.