Pharmaceutical Raw Materials

Alfaxalone (INN, JAN), also known as alphaxalone or alphaxolone (BAN), is a neuroactive steroid and general anaesthetic. It is used in veterinary practice under the trade name Alfaxan, and is licensed for use in both dogs and cats. Along with alfadolone, it is also one of the constituents of anesthetic drug mixture althesin. Unlike some of its predecessors alfaxalone is not associated with histamine release and anaphylaxis.; A study 1987 found the primary mechanism for the anaesthetic action of alfaxalone to be modulation of neuronal cell membrane chloride ion transport, induced by binding of alfaxalone to GABAA cell surface receptors. A 1994 study found that alfaxalone binds to a different region of this receptor than the benzodiazepines. These benzodiazepine-insensitive GABAA receptors are located extrasynaptically and are responsible for tonic inhibition. The occurrence of tonic GABAA inhibition coincides with the expression of relatively rare receptor subunits, particularly the α4, α6, and δ subunits, and as a rule of thumb, δ subunit-containing receptors are extrasynaptic. Alfaxalone is metabolised rapidly in the liver. It has a very short plasma elimination half-life in dogs and cats.

It can be used as an intermediate of cilodoxin.

Delta(9)-tetrahydrocannabinolic acid is a diterpenoid that is 6a,7,8,10a-tetrahydro-6H-benzo[c]chromene substituted at position 1 by a hydroxy group, positions 6, 6 and 9 by methyl groups and at position 3 by a pentyl group. A biosynthetic precursor to Delta(9)-tetrahydrocannabinol, the principal psychoactive constituent of the cannabis plant. It has a role as an anti-inflammatory agent, a neuroprotective agent, a biomarker and a metabolite. It is a diterpenoid, a benzochromene, a hydroxy monocarboxylic acid, a polyketide and a phytocannabinoid. It is a conjugate acid of a Delta(9)-tetrahydrocannabinolate.

Topical antifungal agents for superficial skin fungal infections, including tinea corporis, tinea cruris, tinea manus and pedis, tinea versicolor. But it has no effect on fungal infection of hair and finger (toe) nail.

1、 Conjugated linoleic acid (CLA), extracted from safflower, is a series of double bond linoleic acids. It can scavenge free radicals, enhance the body's antioxidant capacity and immune capacity, promote growth and development, regulate blood cholesterol and triglyceride levels, prevent atherosclerosis, promote lipoxygenation and decomposition, promote human protein synthesis, and comprehensively regulate the body. 2、 Conjugated linoleic acid (CLA) significantly increases the contents of myoglobin in human heart and skeletal muscle. Myoglobin has six times higher affinity for oxygen than hemoglobin. Due to the rapid increase of myoglobin, the ability of human cells to store and transport oxygen is greatly improved, which makes sports training more effective and human vitality more abundant. 3、 Conjugated linoleic acid (CLA) can enhance the fluidity of cell membrane, prevent the proliferation of vascular cortex, maintain the normal function of organ microcirculation, maintain the normal structure and function of cells, enhance the relaxation ability of blood vessels, effectively prevent the damage of human organs and brain caused by severe hypoxia, especially significantly inhibit the edema of lung and spleen caused by severe hypoxia. 4、 According to a foreign patent, CLA can effectively play the role of "blood vessel scavenger", remove the garbage in blood vessels, effectively regulate blood viscosity, relax blood vessels, improve microcirculation and stabilize blood pressure. Some experts also believe that CLA has the function of dilating and relaxing vascular smooth muscle, inhibiting blood movement center, reducing peripheral resistance of blood circulation, reducing blood pressure, especially diastolic pressure.