Lasofoxifene (INN) (brand name Fablyn) is a non-steroidal selective estrogen receptor modulator (SERM) which is marketed by Pfizer for the prevention and treatment of osteoporosis and for the treatment of vaginal atrophy, and the result of an exclusive research collaboration with Ligand Pharmaceuticals (LGND). It also appears to have had a statistically significant effect of reducing breast cancer in women according to a study published in The Journal of the National Cancer Institute.

2-[2-(Diethylamino)Ethoxy]Ethyl 2-Phenylbutanoate

CAS:18109-80-3

Molecular Formula:C18H29NO3

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Butamirato; Butamiratum; Brospamin; Butamirate; Butamyrate

Brief Introduction

Butamirate (or brospamin) is a cough suppressant.A study found it to bind to the cough center in the medulla oblongata, more specifically the dextromethorphan-binding site in guinea pig brain with high affinity.

Valdecoxib

CAS:181695-72-7

Molecular Formula:C16H14N2O3S

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4-(5-Methyl-3-Phenylisoxazol-4-Yl)Benzensulfonamide; Kudeq; 4-(4-Sulfamoylphenyl)-5-Methyl-3-Phenyl-Isoxazole; Valdyn; 4-(5-Methyl-3-Phenyl-1,2-Oxazol-4-Yl)Benzenesulfonamide; 4-(5-Methyl-3-Phenyl-4-Isoxazolyl)Benzenesulfonamide; Bextra; 4-[5-Methyl-3-Phenylisoxazol-4-Yl ] Benzenesulfonamide; Valdecoxib(R); [14C]-Valdecoxib

Brief Introduction

Vardixib is not only the key intermediate in the synthesis of parecoxib sodium, but also its main hydrolysate. It is the main impurity in the inspection of related substances of parecoxib sodium. Parecoxib is a non steroidal anti-inflammatory drug. It is an amide precursor (water-soluble precursor) of varcoxib, a highly selective COX-2 inhibitor. After intravenous administration, parecoxib is rapidly hydrolyzed by carboxylesterase to varcoxib, which plays an anti-inflammatory and analgesic role.

2-(4-Methoxyphenyl)-3-[4-(2-Piperidin-1-Ylethoxy)Phenoxy]-1-Benzothiophen-6-Ol

CAS:182133-25-1

Molecular Formula:C28H29NO4S

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Arzoxifene; Unii-E569Wg6E60; Ly 353381

Brief Introduction

Azoxifen is the third generation of selective estrogen receptor modulator developed by Eli Lilly after raloxifene. It has strong antagonistic activity against estrogen receptors in breast, ovary and endometrium; It can also increase the mineral density of lumbar vertebrae and total hip bones of postmenopausal women with normal or low bone mass, mainly for preventing osteoporosis and preventing breast cancer.

Colesevelam Hydrochloride

CAS:182815-44-7

Molecular Formula:C31H67Cl3N4O

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Colesevelam; 2-(Chloromethyl)Oxirane,Prop-2-En-1-Amine,N-Prop-2-Enyldecan-1-Amine,Trimethyl-[6-(Prop-2-Enylamino)Hexyl]Azanium,Chloride,Hydrochloride; Colesevelam Hcl

Brief Introduction

Coleveren hydrochloride is a non absorbable polymer oral drug. It is a new drug for the treatment of hyperlipidemia developed by an American company. It is suitable for the treatment of high serum total cholesterol (TC) or triglyceride (TG). Clinical studies show that patients can reduce the level of cholesterol by taking coleveren alone within 6 ~ 24 weeks, The level of low density lipoprotein cholesterol (LDL-C) is 9 ~ 19%. When combined with other drugs, it can reduce the level of LDL-C by 10 ~ 16%.

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