API & Intermediate

Valsartan is a specific angiotensin Ⅱ (AT1) receptor antagonist. It is also a non skin AT1 receptor antagonist after losartan. It plays a key role in regulating systemic blood pressure and maintaining electrolyte and body fluid balance. It selectively acts on AT1 receptor subtypes and blocks the binding of Ang Ⅱ to AT1 receptor (its specific antagonistic effect against AT1 receptor is about 20000 times greater than that of AT2 receptor), thus inhibiting vasoconstriction and aldosterone release, resulting in hypotensive effect, but not inhibiting aldosterone release induced by potassium ion (K +). The antihypertensive effect is superior to enalapril in the treatment of hypertension, mild to moderate essential hypertension, especially for secondary hypertension caused by kidney damage. It can significantly reduce proteinuria in hypertensive patients with normal diabetes or normal renal function, and has the protective effect of promoting uric acid and urinary sodium excretion. It is also suitable for reducing the cardiovascular mortality of high-risk patients (left ventricular failure or left ventricular dysfunction) after heart attack.

Levofloxacin lactate is a kind of quinolones, which has broad-spectrum antibacterial effect and strong antibacterial effect. It has strong antibacterial activity against most Enterobacteriaceae, such as Escherichia coli, Klebsiella, proteus, Salmonella, Shigella, Haemophilus influenzae, Legionella pneumophila, Neisseria gonorrhoeae and other gram-negative bacteria.

Irbesartan is an angiotensin II receptor inhibitor, which can be divided into AT1 and AT2. Irbesartan can inhibit the transformation of Ang Ⅰ into ang Ⅱ by selectively blocking the AT1 receptor of ANGLI, and specifically antagonize the angiotensin converting enzyme 1 receptor. The antagonism of irbesartan to AT1 is 8500 times that of AT2, It can inhibit the vasoconstriction and the release of aldosterone. This product does not inhibit angiotensin converting enzyme, renin, other hormone receptors, and ion channels related to blood pressure regulation and sodium balance. Irbesartan is the most effective drug in the treatment of hypertension and cardiovascular disease.

Pantoprazole sodium refers to 5-difluoromethoxy-2 - [(3,4-dimethoxy-2-pyridyl) methyl] sulfinyl-1h-benzimidazole sodium salt. It is an H +, K + - ATPase inhibitor , which can inhibit gastric acid secretion stimulated by various factors such as histamine, gastrin and acetylcholine. It is used to treat diseases related to gastric acid secretion disorders. It has high cure rate, rapid effect and Less adverse reactions.

For tannery tannery, tannery and sheep skins. Suitable store in a cool, dry, and ventilated room. It is best to work with other tanning agents.