Alfacalcitol is a white crystalline or crystalline powder, insoluble in water and hexane, and soluble in methanol, absolute ethanol, chloroform, dichloromethane, acetone or ether. It is easy to deteriorate in case of air and light. Alfacalcitol was first developed by the American bone health international company . Alfacalcitol is mostly used for calcium metabolism disorder caused by vitamin D metabolism disorder. It is clinically used to treat osteoporosis, chronic renal insufficiency, hypothyroidism, anti vitamin D rickets, osteomalacia, etc.