Rubiperidone is a localized chloride channel activator that selectively activates type 2 chloride channels (ClC-2) located on the membrane of luminal cells at the tip of the gastrointestinal epithelium, increasing the secretion of intestinal fluid and intestinal motility, thereby increasing bowel movements, alleviating symptoms of chronic idiopathic constipation, and not altering the concentration of sodium and potassium in plasma.