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Kaifeng Mingren Pharmaceutical Co.,LTD.
Kaifeng Mingren Pharmaceutical Co.,LTD.
22 YRS
Henan, China
Main Products:
Phloroglucinol Anhydrous / Phlorglucinol Dihydrate / Vidarabine Monophosphate / Creatine Phosphate Disodium Salt / 2-[4-(1,3-Benzodioxol-5-Ylmethyl)Piperazin-1-Yl]Pyrimidine / Guanfacine Hydrochloride###Guanfacine Hcl / Fomepizole / Nitisinone / Epalrestat / Nafamostat Mesylate / Doxofylline / (S)-3-Cyano-5-Methylhexanoic Acid Ethyl Ester / 4-(6-Fluoropyridin-3-yl)-6-(2-Hydroxy-2-Methylpropoxy)Pyrazolo[1,5-a]Pyridine-3-Carbonitrile / Methyl 5-((4-Bromo-2-Chlorophenyl)Amino)-4-Fluoro-1-Methyl-1H-Benzo[d]Imidazole-6-Carboxylate / Benzyl (3R,4S)-3-(2-Bromoacetyl)-4-Ethylpyrrolidine-1-Carboxylate / 5-Bromo-4,7-Diazaindole / (2R,3R)-3-(2,5-Difluorophenyl)-3-Hydroxy-2-Methyl-4-(1H-1,2,4-Triazol-1-yl)Butanethioamide / 4-(2-Bromoacetyl)Benzonitrile / Isavuconazole
Henan, China
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Phloroglucinol anhydrous
Phlorglucinol Dihydrate
Vidarabine Monophosphate
Creatine Phosphate Disodium Salt
2-[4-(1,3-Benzodioxol-5-Ylmethyl)Piperazin-1-Yl]Pyrimidine
Guanfacine Hydrochloride###Guanfacine Hcl
Fomepizole
Nitisinone
Epalrestat
Nafamostat Mesylate
Doxofylline
(S)-3-Cyano-5-Methylhexanoic Acid Ethyl Ester
4-(6-Fluoropyridin-3-yl)-6-(2-Hydroxy-2-Methylpropoxy)Pyrazolo[1,5-a]Pyridine-3-Carbonitrile
Methyl 5-((4-Bromo-2-Chlorophenyl)Amino)-4-Fluoro-1-Methyl-1H-Benzo[d]Imidazole-6-Carboxylate
Benzyl (3R,4S)-3-(2-Bromoacetyl)-4-Ethylpyrrolidine-1-Carboxylate
5-Bromo-4,7-Diazaindole
(2R,3R)-3-(2,5-Difluorophenyl)-3-Hydroxy-2-Methyl-4-(1H-1,2,4-Triazol-1-yl)Butanethioamide
4-(2-Bromoacetyl)Benzonitrile
Isavuconazole
Benzyl (3R,4S)-3-(2-Bromoacetyl)-4-Ethylpyrrolidine-1-Carboxylate / CAS 1428243-26-8
OVERVIEW
Packaging
25 KG/Fibre Drum
Lead Time
14-30 days
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DESCRIPTION
Chemical name
English name： Benzyl (3R,4S)-3-(2-Bromoacetyl)-4-Ethylpyrrolidine-1-Carboxylate
CAS No.: 乌帕替尼中间体
Physicochemical properties：
Molecular formula: C16H20BrNO3
Structural type: 
Molecular weight: 354.239
Boiling point: 453.1±45.0 °C(Predicted)
Density： 1.361±0.06 g/cm3(Predicted)
Purpose: Benzyl (3R,4S)-3-(2-bromoacetyl)-4-ethylpyrrolidine-1-carboxylate is a key intermediate of upatinib. At the beginning of 2018, the oral Jak1 selective inhibitor upadacitinib (abt-494), developed by abbvie in the United States once every day for the treatment of adult moderate and severe atopic dermatitis, was recognized as a breakthrough therapy by FDA.
Typical Properties
Summary
Benzyl (3R,4S)-3-(2-bromoacetyl)-4-ethylpyrrolidine-1-carboxylate is a key intermediate of upatinib. At the beginning of 2018, the oral Jak1 selective inhibitor upadacitinib (abt-494), developed by abbvie in the United States once every day for the treatment of adult moderate and severe atopic dermatitis, was recognized as a breakthrough therapy by FDA.
CAS No.
1428243-26-8
Formula
C16H20BrNO3
Molecular Mass
354.23900
Exact Mass
353.06300
PSA
46.61000
Logp
3.18310
IUPAC
benzyl (3R,4S)-3-(2-bromoacetyl)-4-ethylpyrrolidine-1-carboxylate
SMILES
CCC1CN(CC1C(=O)CBr)C(=O)OCC2=CC=CC=C2
Attribute classification
Matter Classification
organic
Category
API & Intermediate > Pharmaceutical Intermediates
Chemical and Physical Properties
Density
1.361±0.06 g/cm3(Predicted)
Boiling Point
453.1±45.0 °C(Predicted)
Export information
HS Code
29339900
Export Rebate
13%
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