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Kaifeng Mingren Pharmaceutical Co.,LTD.

22 YRS

Henan, China

CNY 50 Million

35298 m²

100-500 people

Main Products: Phloroglucinol Anhydrous / Phlorglucinol Dihydrate / Vidarabine Monophosphate / Creatine Phosphate Disodium Salt / 2-[4-(1,3-Benzodioxol-5-Ylmethyl)Piperazin-1-Yl]Pyrimidine / Guanfacine Hydrochloride###Guanfacine Hcl / Fomepizole / Nitisinone / Epalrestat / Nafamostat Mesylate / Doxofylline / (S)-3-Cyano-5-Methylhexanoic Acid Ethyl Ester / 4-(6-Fluoropyridin-3-yl)-6-(2-Hydroxy-2-Methylpropoxy)Pyrazolo[1,5-a]Pyridine-3-Carbonitrile / Methyl 5-((4-Bromo-2-Chlorophenyl)Amino)-4-Fluoro-1-Methyl-1H-Benzo[d]Imidazole-6-Carboxylate / Benzyl (3R,4S)-3-(2-Bromoacetyl)-4-Ethylpyrrolidine-1-Carboxylate / 5-Bromo-4,7-Diazaindole / (2R,3R)-3-(2,5-Difluorophenyl)-3-Hydroxy-2-Methyl-4-(1H-1,2,4-Triazol-1-yl)Butanethioamide / 4-(2-Bromoacetyl)Benzonitrile / Isavuconazole

Henan, China

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Epalrestat / CAS 82159-09-9

OVERVIEW

Packaging

25 KG/Fibre Drum

Lead Time

14-30 days

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DESCRIPTION

English Name: Epalrestat

English alias: (E, e) - 2 - [5 - (2-methyl-3-phenyl-prop-2-enylidene) - 4-oxo-2-sulfanylidene-thiazo lidin-3-yl] acetic acid

Molecular formula: C15H13NO3S2

Structural formula：

Molecular weight: 319.40

Property description

Form: Powder

Color: yellow to orange

Melting point: 210-217 ° C

Boiling point: 516.8 ± 60.0 ° C (predicted)

Density: 1.43 ± 0.1 g / cm3 (predicted)

Storage conditions: - 20 ° C

Soluble in tetrahydrofuran, more soluble in dimethylformamide, less soluble in methanol, ethanol, ethyl acetate or acetone, less soluble in chloroform or ether, and almost insoluble in water.

Melting point 210 ~ 217 ℃ (ethanol water).

Product application: aldose reductase inhibitor.

Typical Properties

Epalrestat is a carboxylic acid derivative and a noncompetitive and reversible aldose reductase inhibitor used for the treatment of diabetic neuropathy, which is one of the most common long-term complications in patients with diabetes mellitus. It reduces the accumulation of intracellular sorbitol which is believed to be the cause of diabetic neuropathy, retinopathy and nephropathy It is well tolerated, with the most commonly reported adverse effects being gastrointestinal issues such as nausea and vomiting, as well as increases in certain liver enzymes. Chemically, epalrestat is unusual in that it is a drug that contains a rhodanine group. Aldose reductase is the key enzyme in the polyol pathway whose enhanced activity is the basis of diabetic neuropathy. Aldose reductase inhibitors (ARI) target this enzyme. Out of the many ARIs developed, ranirestat and fidarestat are in the trial stage. Others have been discarded due to unacceptable adverse effects or weak efficacy. Epalrestat is the only ARI commercially available. It is easily absorbed into the neural tissue and inhibits the enzyme with minimum side effects.

CAS No.

82159-09-9

Formula

C15H13NO3S2

Molecular Mass

319.39900

Exact Mass

319.03400

PSA

115.00000

Logp

2.85660

IUPAC

2-[(5Z)-5-[(E)-2-methyl-3-phenylprop-2-enylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]acetic acid

SMILES

CC(=CC1=CC=CC=C1)C=C2C(=O)N(C(=S)S2)CC(=O)O

Matter Classification

organic

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