O-Chlorophenol
Product Introduction
It is a kind of monochloro derivative of phenol with a formula of ClC6H4OH and with three isomers as o-chlorophenol, m-chlorophenol, and p-chlorophenol. The o-chlorophenol is a kind of colorless liquid with the melting point of 9.0 ° C, the boiling point of 174.9 ° C, the relative density of 1.2634 (20/4 ° C); it is soluble in alcohol, ether, benzene, alkaline aqueous solution, slightly soluble in water. The m-chlorophenol is a kind of colorless solid with the melting point of 33 ° C, the boiling point of 214 ° C, the density of 1.268 g / cm 3 (25 ° C); it is soluble in alcohol, ether, benzene, alkaline aqueous solution. The p-chlorophenol is a kind of colorless solid with the melting point of 43 ~ 44 ° C, boiling point of 219.7 ° C; it is soluble in alcohol, ether, benzene.
The o-and p-chlorophenol are directly derived from the chlorination of phenol. Intra-molecular association reaction occurred in the former, the boiling point of which is lower than the p-chlorophenol in which the intermolecular occurred, so that the two isomers can be separated by distilling. The m-chlorophenol can be produced by other methods. For example: the above-mentioned methods can be utilized in industry and laboratory. When the phenol receives direct chlorination, if the amount of chlorine is large enough, the phenol can generate 2, 4, 6- trichlorophenol. If hypochlorite is used with phenol, it will only generate o-chlorophenol. In carbon tetrachloride, the hypochlorous tert-butyl ester can react with phenol only to generate o-chlorophenol: phenol and sulfuryl chloride SO2Cl2 will react to form o-chlorophenol and p-chlorophenol; after the vacuum distillation, we can get 62% of p-chlorophenol.
Applications
Chlorophenol, a kind of bactericide and preservative stronger than the phenol, is a kind of important industrial raw material which can also be used as a local disinfectant.
Chlorophenol can be absorbed through skin contact, and it can damage the liver, kidney and lung. It is more poisonous when dissolved in solvent; if inhaled, it can cause accelerated breathing, high blood pressure, fever, increased peristalsis, nervus motorius asthenia, collapse, spasm and even death.
2-Chlorophenol is mainly used in pesticide, medicine, dyestuff, plastics and other industries. It is also used as denaturant of alcohol and selective solvent of refined mineral oil. It can also be used for microscope analysis and plant growth promoter. It can be used to synthesize dyes and react with dilute nitric acid to form mononitro and dinitro compounds, which are dye intermediates. It can further synthesize a variety of dyes, such as neutral brilliant green BL, etc. It is also used as denaturant for alcohol and selective solvent for refining mineral oil. In the pesticide industry, it is mainly used for the synthesis of Triadimefon, imipramine, wool fungicide, anti falling hormone (multifunctional plant growth regulator), propafenone (internal insecticide), tetraphos, insecticide, acaricide (Non internal acaricide), acaricide and dicofofen; In the pharmaceutical industry, it is used for carboxylation of sodium 5-chloro-2-hydroxybenzoate, synthesis of antomin, p-chlorophenoxyisobutyric acid and other drugs; It is also used in the synthesis of antioxidant BHA.
SMILES
C1=CC=C(C(=C1)O)Cl
Shandong, China
