P-Chlorophenol
Product ntroduction
It is a kind of monochloro derivative of phenol with a formula of ClC6H4OH and with three isomers as o-chlorophenol, m-chlorophenol, and p-chlorophenol. The o-chlorophenol is a kind of colorless liquid with the melting point of 9.0 ° C, the boiling point of 174.9 ° C, the relative density of 1.2634 (20/4 ° C); it is soluble in alcohol, ether, benzene, alkaline aqueous solution, slightly soluble in water. The m-chlorophenol is a kind of colorless solid with the melting point of 33 ° C, the boiling point of 214 ° C, the density of 1.268 g / cm 3 (25 ° C); it is soluble in alcohol, ether, benzene, alkaline aqueous solution. The p-chlorophenol is a kind of colorless solid with the melting point of 43 ~ 44 ° C, boiling point of 219.7 ° C; it is soluble in alcohol, ether, benzene.
The o-and p-chlorophenol are directly derived from the chlorination of phenol. Intra-molecular association reaction occurred in the former, the boiling point of which is lower than the p-chlorophenol in which the intermolecular occurred, so that the two isomers can be separated by distilling. The m-chlorophenol can be produced by other methods. For example: the above-mentioned methods can be utilized in industry and laboratory. When the phenol receives direct chlorination, if the amount of chlorine is large enough, the phenol can generate 2, 4, 6- trichlorophenol. If hypochlorite is used with phenol, it will only generate o-chlorophenol. In carbon tetrachloride, the hypochlorous tert-butyl ester can react with phenol only to generate o-chlorophenol: phenol and sulfuryl chloride SO2Cl2 will react to form o-chlorophenol and p-chlorophenol; after the vacuum distillation, we can get 62% of p-chlorophenol.
Applications
Chlorophenol, a kind of bactericide and preservative stronger than the phenol, is a kind of important industrial raw material which can also be used as a local disinfectant.
Chlorophenol can be absorbed through skin contact, and it can damage the liver, kidney and lung. It is more poisonous when dissolved in solvent; if inhaled, it can cause accelerated breathing, high blood pressure, fever, increased peristalsis, nervus motorius asthenia, collapse, spasm and even death.
Pure p-chlorophenol is white crystal, industrial product is yellow or pink crystal, almost insoluble in water, soluble in benzene, ethanol, ether, glycerol, chloroform, fixed oil and volatile oil. This product is mainly used for microscopic analysis, pharmaceutical and dye intermediates, alcohol denaturant and solvent, etc. it is also used as selective solvent for refining mineral oil. In the agricultural industry, it is mainly used for the synthesis of Triadimefon, Verbenone, wool fungicide, clozapine, propafenone, tetraphos, insecticide, etc. it is also used for the manufacture of pesticide fungicide 5,5 'dichloro-2,2' dihydroxydiphenylmethane and plant growth promoter. Dyestuff industry is used to produce 1,4-Dihydroxyanthraquinone, 1,4-diaminoanthraquinone, p-aminophenol and hydroquinone. The pharmaceutical industry is used for carboxylation of sodium 5-chloro-2-hydroxybenzoate, synthesis of p-chlorophenoxyisobutyric acid and other drugs, and synthesis of antioxidant BHA (butyl hydroxyanisole).
Shandong, China
