Synopsis:Nystatin is a kind of polyene antifungal agent with conjugated polyene macrolide structure, which can inhibit the activity of fungi, but has no inhibitory effect on bacteria. The combination of nystatin and sterols on fungal cell membrane results in the change of cell membrane permeability, leading to the leakage of important cell contents. Nystatin has many applications, such as preventing cell culture contamination and inducing interleukin, IL-8 and TLR2 to express tumor necrosis factor secreted by THP1- α。 Nystatin is used as a fungal membrane pore forming agent and to create nystatin / p-ergosterol ion channels in lipid bilayers.
Structural formula:
Properties
Summary
Nystatin is a kind of polyene antifungal agent with conjugated polyene macrolide structure, which can inhibit the activity of fungi, but has no inhibitory effect on bacteria. The combination of nystatin and sterols on fungal cell membrane results in the change of cell membrane permeability, leading to the leakage of important cell contents. Nystatin has many applications, such as preventing cell culture contamination and inducing interleukin, IL-8 and TLR2 to express tumor necrosis factor secreted by THP1- α。 Nystatin is used as a fungal membrane pore forming agent and to create nystatin / p-ergosterol ion channels in lipid bilayers.
Manufacturing
