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Jiangsu Simcere Pharmaceutical Co., Ltd.

29 YRS

Jiangsu, China

CNY 568.8 Million

219780 m²

Over 1000 people

Main Products: Posaconazole / Diosmectite / Zanamivir / Palonosetron Hydrochloride / Pemetrexed Disodium / Bendamustine HCl / Palbociclib / Cabozantinib Malate / Ibrutinib / Edoxaban(Tosylate Monohydrate) / Bedaquiline Fumarate / Apremilast

Jiangsu, China

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Palonosetron Hydrochloride / CAS 135729-62-3

OVERVIEW

Packaging

25 KG/Fibre Drum

Lead Time

14-30 days

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DESCRIPTION

Palonosetron Hydrochloride

Pharmacological action:

Palonosetron is a selective antagonist of 5-HT3 receptor with strong affinity, and has no affinity or low affinity for other receptors. The 5-HT3 receptor is located in the central and peripheral vagus nerve endings of the emetic and chemotherapy sensing area in the last area of the medulla oblongata. Chemotherapeutic drugs stimulate small intestinal chromaffin cells to release 5-HT, which reactivates the 5-HT3 receptor of vagal afferent nerve to produce vomiting reflex.

Indication:

· Prevent acute nausea and vomiting caused by severe emetic chemotherapy.

· Prevent nausea and vomiting caused by moderate emetic chemotherapy.

Adverse reactions:

According to foreign clinical research reports, 1374 adult patients participated in the clinical study of palonosetron in preventing nausea and vomiting caused by moderate or high emetic chemotherapy. The results showed that the incidence and severity of adverse reactions caused by palonosetron were similar to ondansetron or dorasetron.

Taboos:

It is prohibited to use in patients who are known to be allergic to the drug or any component of the drug.

Synonymous：	Benz[De]Isoquinolin-1-One Hydrochloride
CAS：	135729-62-3
Molecular Formula：	C₁₉H₂₅ClN₂O
Molecular Weight：	332.868
Appearance：	White powder
Storage：	Store at room temperature (10 ~ 30 ℃) in a closed manner, away from light and antifreeze
Category：	For chemotherapy-induced vomiting inhibitors

Typical Properties

Palonosetron hydrochloride is a serotonin 5-HT3 receptor antagonist used to prevent and treat chemotherapy-induced nausea and vomiting (CINV).

CAS No.

135729-62-3

Formula

C19H25ClN2O

Molecular Mass

332.86800

Exact Mass

332.16600

PSA

23.55000

Logp

3.33430

IUPAC

(3aS)-2-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-3a,4,5,6-tetrahydro-3H-benzo[de]isoquinolin-1-one;hydrochloride

SMILES

C1C[C@@H]2CN(C(=O)C3=CC=CC(=C23)C1)[C@@H]4CN5CCC4CC5.Cl

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