Rabeprazole / CAS 117976-89-3

Name in English:

Rabeprazole

CAS No

117976-89-3

Molecular formula:

C18H21N3O3S

Molecular weight:

359.44

Proton pump inhibitor

Rabeprazole is a novel benzimidazole proton pump inhibitor, a genus of antiulcer agents, which can be activated within the acidic gastric parietal cells to inhibit gastric acid secretion by bonding with the gastric intraluminal proton pump. Rabeprazole can specifically inhibit the action of triphosphatase adenosine - nase, a key enzyme in gastric acid production. There is an inhibitory effect on both basal gastric acid and gastric acid secretion caused by stimulation. Bioavailability was not affected by food or antacids and there was no interaction with antacids. It is indicated for the treatment of peptic ulcer, upper gastrointestinal bleeding, pancreatic ulcer syndrome and reflux esophagitis, and synergistically treats Helicobacter pylori infection. The possibility of malignant lesions should be excluded before use.

Properties

White yellowish white powder, odorless, molecular weight 381.43. This product is very soluble in water or methanol, absolute ethanol or ethyl acetate, and almost insoluble in ether or ethane. The product does not show optical rotation and has temperature absorption. Its melting point is 225 ℃, and the partition coefficient in water / octane system with pH value of 7.0 is about 214. This product is a light yellow film coated tablet (enteric coated tablet).