Grape Seed Extract / CAS 84929-27-1

【 Name in English 】 Grape Seed Extract

【CAS No. 84929-27-1

【 Molecular formula 】 C₃₂H₃₀O₁₁

【 Molecular weight】 590.574

【 EINECS No.】 284-511-6

【 Introduction 】 Grape seed extract is a polyphenol extracted from grape seeds, and the main active ingredient is a low-molecular-weight aggregate of proanthocyanidin, which is an edible product. It is a powerful antioxidant and a highly effective free radical scavenger. Used in food supplements, health foods, and cosmetics, among others.

【 Trait 】 The grape seed extract is a brownish red powder. Medicinal value of grape seeds grape seeds have the efficacy of " Tonifying Qi, strengthening fascicles and making small stools, and curing weakness of Qi and blood, deficiency cough of the lung, night sweats with palpitations, rheumatic Bi ache, gonorrhoea, and edema ", and modern studies have shown that procyanidin glycosides from grape seed extracts are functional as antioxidants and reduce cholesterol levels, making them a highly potential natural antioxidant, It can be used to prevent high cholesterol, atherosclerosis, cataracts, gastric ulcers, intestinal adenocarcinoma, Ehrlich ascites carcinoma and so on.

The main pharmacological effects are as follows:

1 、 Antioxidant effects: polyphenols in grape seed extract include phenolic hydroxyl groups of proanthocyanidins and gallic acids, providing hydrogen atoms while having specific powerful antioxidant effects. The ability to neutralize iron ions and oxygen that attack lipids is 15 - to 25 fold that of VB, which scavenges free radicals than VC Strong antioxidant such as ve.

2 、 Radioprotective effect: it can inhibit radiation triggered lipid peroxidation.

3 、 Anti inflammatory effect: the main component is proanthocyanidins, whose antioxidant activity can inhibit the synthesis and release of inflammatory factors such as histamine, serotonin, prostaglandins, and leukotrienes, inhibit the release of granules from basophils and mast cells, and also can inhibit histamine decarboxylase activity and limit the action of hyaluronidase.

4, Cataract prevention effect: the main component of cataract prevention is catechin; Grape seed extract improves visual acuity and may improve ocular fatigue in patients with myopic retinal non inflammatory changes.

5 、Anticancer effects: it is cytotoxic against MCF-7 human breast cancer cells, a-427 human lung cancer cells, and crl1739 human gastric adenocarcinoma cells and prevents the carcinogenic effects of intestinal chemical carcinogens.

6,Antiatherosclerotic effect: foods containing 2.5% grape seed extract reduce cholesteryl ester peroxide levels in the serum of experimental animals and also lower LDL to combat atherosclerosis. May improve hemorheological indices and platelet aggregation.

7, Cholesterol lowering effect: galloyl ester tannins have been shown to reduce plasma total, triglyceride, low - and very low-density cholesterol levels and to increase high-density cholesterol levels.

8 , Antiulcer effect: the oligomeric proanthocyanidins from grape seed extract protect gastric mucosal damage, proanthocyanidins have the effect of scavenging free radicals on the gastric surface and protecting the gastric wall.

9, Antimutation effect: may reduce the incidence of mitochondrial mutations and the incidence of nuclear mutations. Introduction grape seed extracts are polyphenols extracted from grape seeds and the main active ingredient is a low molecular weight aggregate of proanthocyanidins, which are edible products. It is a powerful antioxidant and a highly effective free radical scavenger. Used in food supplements, health foods, and cosmetics, among others.