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Xi'an Guokang Ruijin Pharmaceutical Co.,Ltd.
Xi'an Guokang Ruijin Pharmaceutical Co.,Ltd.
6 YRS
Shaanxi, China
Main Products:
Dexamethasone Sodium Phosphate / Dexamethasone / Dexamethasone Acetate / Betamethasone / Progesterone / Sofosbuvir
Shaanxi, China
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Sofosbuvir / CAS 1190307-88-0
OVERVIEW
Packaging
25 KG/Fibre Drum
Lead Time
14-30 days
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DESCRIPTION
Sofosbuvir
【Specifications】1kg/tin,5kg/tin
【Appearance】White powder
【Solubility】Slightly soluble in water (pH 1.2-7.7), freely soluble in ethanol and acetone, soluble in ISO acetone, insoluble in heptane.。
【Melting point】118℃ -128℃
【Water content】≤0.5%
【Heavy metal】≤20ppm
【Chiral purity】RP isomer ≤ 0.15%
【Content】98.0% — 102.0%
【Storage】Shade, seal and store in a dry place.
【Chemical structural formula】
Typical Properties
Summary
Sofibibuvir is a prodrug, which can be metabolized to 2 '- deoxy-2' - deoxy-2 '- α- Fluorine- β- C-methyluridine-5 '- monophosphate, used in the treatment of hepatitis C. Sofibvir is a direct acting antiviral drug, which inhibits HCV RNA dependent RNA polymerase, NS5B Gene. NS5B Gene is essential for HCV replication.
CAS No.
1190307-88-0
Formula
C22H29FN3O9P
Molecular Mass
529.45300
Exact Mass
529.16300
PSA
167.99000
Logp
2.04740
IUPAC
propan-2-yl (2S)-2-[[[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate
SMILES
CC(C)OC(=O)C(C)NP(=O)(OCC1C(C(C(O1)N2C=CC(=O)NC2=O)(C)F)O)OC3=CC=CC=C3
Attribute classification
Matter Classification
organic
Category
API & Intermediate > Synthetic Anti Infective Drugs
Chemical and Physical Properties
Density
1.41 g/cm3
Appearance
White to almost white crystalline solid
Export information
HS Code
29349990
Export Rebate
10%
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