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Zhejiang Hisoar Pharmaceutical Co.,Ltd.

26 YRS

Zhejiang, China

CNY 1618.7 Million

59940 m²

Over 1000 people

Main Products: Clindamycin Phosphate / Clindamycin Palmitate HCl / Clindamycin Hydrochloride Monohydrate / Meropenem / Thiamphenicol / Amorolfine Hydrochloride / Bifendate / Phenylephrine Hydrochloride / Metroprolol Succinate / Quetiapine Fumarate / Repaglinide / Sulfasalazine / Sulfapyridine / Voglibose / Blue Base P-3R

Zhejiang, China

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Quetiapine Fumarate / CAS 111974-72-2

OVERVIEW

Packaging

25 KG/Fibre Drum

Lead Time

14-30 days

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DESCRIPTION

Quetiapine fumarate

Product introduction:

Quetiapine fumarate is an atypical antipsychotic drug that interacts with a variety of neurotransmitter receptors. In the brain, quetiapine has a high affinity for serotonin (5ht2) receptors, which is greater than that for dopamine D1 and dopamine D2 receptors in the brain. Quetiapine has a high affinity for histamine receptors and adrenergic receptors α Receptor 1 also has high affinity for adrenaline α 2 receptor has low affinity, but has little affinity for cholinergic muscarinic receptor or benzodiazepine receptor. Quetiapine showed positive results in antipsychotic activity and conditioned avoidance reflex. Clinical trials show that this drug is effective in the treatment of positive and negative symptoms of schizophrenia.

CAS：111974-72-2

Molecular formula: C46H54N6O8S2

Molecular weight: 883.09

Structural type:

Usage: A non classical antipsychotic drug

Typical Properties

Quetiapine fumarate is a new atypical antipsychotic drug, which belongs to dibenzothiazide derivatives. Quetiapine fumarate can bind to Da's D1, D2 and 5-HT receptors, and has stronger affinity for 5-HT receptors than D and D2 receptors. Therefore, quetiapine fumarate has better sedative effect, less adverse reactions, and strengthens the clinical adaptability of the drug. It can play a better curative effect in a short time, reduce the incidence of manic episode and improve the clinical symptoms.

CAS No.

111974-72-2

Formula

C46H54N6O8S2

Molecular Mass

883.08600

Exact Mass

882.34400

PSA

221.80000

Logp

4.04660

IUPAC

2-[2-(4-benzo[b][1,4]benzothiazepin-6-ylpiperazin-1-yl)ethoxy]ethanol;(E)-but-2-enedioic acid

SMILES

C1CN(CCN1CCOCCO)C2=NC3=CC=CC=C3SC4=CC=CC=C42.C1CN(CCN1CCOCCO)C2=NC3=CC=CC=C3SC4=CC=CC=C42.C(=CC(=O)O)C(=O)O

Matter Classification

organic

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