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Jiangsu Zhongbang Pharmaceutical Co., Ltd.

23 YRS

Jiangsu, China

CNY 180 Million

466200 m²

500-1000 people

Main Products: Telmisartan / Irbesartan / Olmesartan Medoxomi / Valsartan / Candesartan Cilexetil / Esomeprazole Magnesium Trihydrate / Sodium (S)-6-Methoxy-2-(((4-Methoxy-3,5-Dimethylpyridin-2-yl)Methyl)Sulfinyl)Benzo[d]Imidazol-1-ide / Lansoprazole / 5-Methoxy-2-{[(4-Methoxy-3,5-Dimethylpyridin-2-Yl)Methyl]Sulfinyl}-1H-Benzimidazole / Nevirapine / Efavirenz

Jiangsu, China

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5-Methoxy-2-{[(4-Methoxy-3,5-Dimethylpyridin-2-Yl)Methyl]Sulfinyl}-1H-Benzimidazole

5-Methoxy-2-{[(4-Methoxy-3,5-Dimethylpyridin-2-Yl)Methyl]Sulfinyl}-1H-Benzimidazole / CAS 73590-58-6

OVERVIEW

Packaging

25 KG/Fibre Drum

Lead Time

14-30 days

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DESCRIPTION

Omeprazole

CAS:73590-58-6

Molecular formula：C₁₇H₁₉N₃O₃S

Molecular weight：345.41600

Appearance:White crystalline solid

Synopsis:Omeprazole is a proton pump inhibitor used in the treatment of peptic ulcer and gastroesophageal reflux disease. It can specifically act on the site of proton pump in gastric parietal cells and convert into the active form of sulphonamide. Then it can irreversibly combine with the sulfhydryl group of proton pump through disulfide bond to form a complex of sulphonamide and proton pump (H + - K + - ATPase), Therefore, inhibiting the activity of the enzyme can prevent the H + in parietal cells from being transported to the gastric cavity, and block the last step of gastric acid secretion, which can greatly reduce the amount of gastric acid in gastric juice. Therefore, this product has a strong and lasting inhibitory effect on gastric acid secretion caused by various reasons (such as basic gastric acid secretion, gastric acid secretion caused by histamine, pentagastrin and stimulation of vagus nerve, including gastric acid secretion caused by dibutyl camp, which cannot be inhibited by H2 receptor blockers). This is related to the irreversibility of the inhibitory effect of the product on proton pump. Only after the formation of a new proton pump can the acid secretion recover.

Structural formula:

Typical Properties

Omeprazole is a proton pump inhibitor used in the treatment of peptic ulcer and gastroesophageal reflux disease. It can specifically act on the site of proton pump in gastric parietal cells and convert into the active form of sulphonamide. Then it can irreversibly combine with the sulfhydryl group of proton pump through disulfide bond to form a complex of sulphonamide and proton pump (H + - K + - ATPase), Therefore, inhibiting the activity of the enzyme can prevent the H + in parietal cells from being transported to the gastric cavity, and block the last step of gastric acid secretion, which can greatly reduce the amount of gastric acid in gastric juice. Therefore, this product has a strong and lasting inhibitory effect on gastric acid secretion caused by various reasons (such as basic gastric acid secretion, gastric acid secretion caused by histamine, pentagastrin and stimulation of vagus nerve, including gastric acid secretion caused by dibutyl camp, which cannot be inhibited by H2 receptor blockers). This is related to the irreversibility of the inhibitory effect of the product on proton pump. Only after the formation of a new proton pump can the acid secretion recover.

CAS No.

73590-58-6

Formula

C17H19N3O3S

Molecular Mass

345.41600

Exact Mass

345.11500

PSA

96.31000

Logp

3.76540

IUPAC

6-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1H-benzimidazole

SMILES

CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C(N2)C=C(C=C3)OC

Matter Classification

organic

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