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Xinyu Pharmaceutical Co.,Ltd.

24 YRS

Anhui, China

CNY 90 Million

333000 m²

500-1000 people

Main Products: Clindamycin Phosphate / Lincomycin Hydrochloride Monohydrate / Clindamycin Hydrochloride Monohydrate / Neomycin Sulfate / Moxidectin / Lincomycin Hydrochloride

Anhui, China

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Neomycin Sulfate / CAS 1405-10-3

OVERVIEW

Packaging

20 KG/Fibre Drum

Lead Time

14-30 days

Max Capacity

800 MT/Year

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DESCRIPTION

Neomycin Sulphate

Product Category:BAPI for veterinary use

Cas.NO:1405-10-3

Quality standard:CvP, EP, USP

Approval number of veterinary drug products:ShouYaoYuanZi120541519

Specification:active pharmaceutical ingredients

Molecular formula:C₃₇H₅₃NO₈

Molecular weight:639.82

To use:aminoglycoside antibiotics. Used for colibacillosis caused by gram-negative bacteria such as avian colibacillosis and salmonella, pullorum of chicken etc.

Pharmacodynamics Neomycin belongs to aminoglycoside antimicrobial drug, antibacterial spectrum and kanamycin are similar. It has a strong antibacterial effect on most gram-negative bacilli, such as escherichia coli, proteus, salmonella and pasteurella multocides, and is also sensitive to staphylococcus aureus.

Storage:seal and store in a dry place.

Typical Properties

Neomycin Sulfate is the sulfate salt form of neomycin, a broad spectrum aminoglycoside antibiotic derived from Streptomyces fradiae with antibacterial activity. Neomycin is an antibiotic complex consisting of 3 components: the two isomeric components B and C are the active components, and neomycin A is the minor component. Neomycin irreversibly binds to the 16S rRNA and S12 protein of the bacterial 30S ribosomal subunit. As a result, this agent interferes with the assembly of initiation complex between mRNA and the bacterial ribosome, thereby inhibiting the initiation of protein synthesis. In addition, neomycin induces misreading of the mRNA template and causes translational frameshift, thereby results in premature termination. This eventually leads to bacterial cell death.

CAS No.

1405-10-3

Formula

C23H48N6O17S

Molecular Mass

712.722

Exact Mass

712.28

PSA

436.09000

Logp

-4.26550

IUPAC

(2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol;sulfuric acid

SMILES

C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N.OS(=O)(=O)O

Matter Classification

organic

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