L- Arabinose
Name: L-Arabinose
Another name: L (+) – gum aldose, pectose
Molecular formula: C5H10O5
Molecular weight: 150.13
Specific gravity: 1.585
Melting point: 154~158 C
Sweetness: 50%of sucrose
Optical rotation: +100 ~ +104 degrees (C=5, H2O, 24h)
Solubility: soluble in water, slightly soluble in ethanoll, insoluble in ether methanol or acetone.
Character: white crystalline powder.
Functional characteristics
1、L-arabinose can improve the metabolism and absorption of sucrose. The most representative physiological function of L-arabinose is to selectively inhibit the activity of sucrase in the small intestine, thereby，It inhibits the absorption of sucrose in the form of glucose and fructose. It can also inhibit the increase of blood sugar caused by sucrose intake, prevent and treat diseases related to high blood sugar, and improve the glucose tolerance of type II urine patients.
2、It can inhibit the activity of alpha glucosidase ,effectively reduced postprandial sugar levels.
3、It can reduce the activity of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in serum, alleviate the damage of diabetes mellitus to liver tissue and protect liver.
4. Low absorption rateo of L-arbinose in human intestine can promote the growth of bifidobacteria, prevent constipation and improve intestinal health.
5. L-arabinose can change the ratio of skeletal muscle fibers and influence the growth of abdominal adipose tissue by controlling glycolysis to glycolysis. The change of the ratio of skeletal muscle fibers is beneficial to the hypoglycemia of type 2 diabetes mellitus.
6. Pharmaceutical raw materials: Under the action of various new catalysts. L-arabinose as an important synthetic material, can effectively synthesize L-ribose, cytarabine, adenosine arabinose, D-ribose, deoxyribose and so on .
7. Medicinal Intermediates: Nucleoside antiviral drugs can also be synthesized, such as L-arabinose as the precursor, through a 10-step process to finally synthesize anti-hepatitis B virus and anti-Ep-stein-Barr virus active reagent 1-(2-fluoro-5-methyl-beta-L-arabinose) -uracil (L-FMAU).
Application area
1.Food and beverages: diabetic food, diet food, health functional food, sucrose additives.
2.Additives for confectionery, baking food and milk.
3.Drugs: L-arabinose can be used as additives or excipients of proprietary medicines in Prescription and OTC drugs for glucose control and weight loss.
4.Flavors and fragrances: L-arabinose was used to produce reactive flavors.
5. Intermediates in drug synthesis: it can be used to synthesize cytarabine, adenosine arabinoside, L-ribose, deoxyribose, antiviral drugs such as telmivudine, lamivudine, etc.
6. As components of organic synthesis, chemical reagents and biochemical bacteria culture medium;
7. Pharmaceutical excipients and fillers: L-arabinose can be used as excipients and fillers in different dosage forms, such as cough syrup, tablets and so on, because of its stable structure, heat resistance, calorie free and similar sweetness to sucrose.
Shandong, China
