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NANJING DAOGE BIOPHARMA CO.,LTD.

3 YRS

Jiangsu, China

CNY 1 Million

Less than 50 people

Main Products: Diphenyliodonium Trifluoromethanesulfonate / Butanedihydrazide / Isophthalic Dihydrazide / 3,5-Dimethylpyrazole / Terephthalic Dihydrazide / Dodecanediohydrazide / Sebacic Dihydrazide / Adipic Dihydrazide / Decanedihydrazide / 1-Cyclopropyl-6,7-Difluoro-1,4-Dihydro-4-Oxoquinoline-3-Carboxylic Acid / 5-Amino-2,3-Dichloropyridine / 4-(2-Furyl)-3-Buten-2-One / 4-Ethyltoluene / Ethyl 2-[4-(2-Bromoacetyl)Phenyl]-2-Methylpropanoate / 1,3-Dihydroxyadamantane / Methyl (1R,3R)-1-(1,3-Benzodioxol-5-Yl)-2,3,4,9-Tetrahydro-1H-Pyrido[3,4-B]Indole-3-Carboxylate,Hydrochloride / Cyanoacetic ACID-OSU / (1R,3R)-Methyl 1-(Benzo[D][1,3]Dioxol-5-Yl)-2-(2-Chloroacetyl)-2,3,4,9-Tetrahydro-1H-Pyrido[3,4-B]Indole-3-Carboxylate / Lysidine / Naphthazarin / 6-Chloro-2-Methoxy-3-Nitropyridine / Diisopropylcyanamide / 8-Azaadebine / 3,4-Epoxytetrahydrofuran / Nonivamide / 4,6-Diaminopyrimidine / Methyl 2,3-Dihydroxybenzoate / 5-Formyl-2-Furancarboxylic Acid / 3,4-(Methylenedioxy)Cinnamic Acid / 4-Isopropylresorcinol / 4-Vinylbenzoic Acid / 2,6-Dimethoxy-3-Nitropyridine / 5-Nitro-6-Methyluracil / 5-Formyl-2-Furancarboxylic ACID / 2-Bromo-5-Nitroaniline / 8-Bromo-1H-Purine-2,6(3H,7H)-Dione / Methyl Nonadecanoate

Jiangsu, China

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(1R,3R)-Methyl 1-(Benzo[D][1,3]Dioxol-5-Yl)-2-(2-Chloroacetyl)-2,3,4,9-Tetrahydro-1H-Pyrido[3,4-B]Indole-3-Carboxylate

(1R,3R)-Methyl 1-(Benzo[D][1,3]Dioxol-5-Yl)-2-(2-Chloroacetyl)-2,3,4,9-Tetrahydro-1H-Pyrido[3,4-B]Indole-3-Carboxylate / CAS 171489-59-1

OVERVIEW

Uses

Tildenafil Tildenafil

Packaging

25 KG/Fibre Drum

Lead Time

30-60 days

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DESCRIPTION

(1R,3R)-Methyl 1-(Benzo[D][1,3]Dioxol-5-Yl)-2-(2-Chloroacetyl)-2,3,4,9-Tetrahydro-1H-Pyrido[3,4-B]Indole-3-Carboxylate

English Name: (1R,3R)-Methyl 1-(Benzo[D][1,3]Dioxol-5-Yl)-2-(2-Chloroacetyl)-2,3,4,9-Tetrahydro-1H-Pyrido[3,4-B]Indole-3-Carboxylate

CAS No.: 171489-59-1

Molecular formula: C22H19ClN2O5

Molecular weight: 426.85

Melting point: 230-232 ℃

Boiling point: 627.5 ± 55.0 ° C (predicted)

Density: 1.445g/cm3

Application: tadalafil intermediate can be used as organic synthesis intermediate and pharmaceutical intermediate, and can be used in laboratory R & D process and chemical pharmaceutical synthesis process.

Typical Properties

This product is an intermediate of tadalafil, which can be used in laboratory research and development process and chemical medicine synthesis process. Tadalafil is a selective reversible inhibitor of cyclic guanosine monophosphate (CGMP) - specific phosphodiesterase 5 (PDE5). When sexual stimulation results in the local release of nitric oxide, PDE5 is inhibited by tadalafil, which increases the cGMP level in the penile cavernous body, resulting in relaxation of smooth muscle, blood flow into the penile tissue, and erection, such as asexual stimulation.

CAS No.

171489-59-1

Formula

C22H19N2O5Cl

Molecular Mass

426.84966

Exact Mass

426.09800

PSA

80.86000

Logp

3.08900

IUPAC

methyl (1R,3R)-1-(1,3-benzodioxol-5-yl)-2-(2-chloroacetyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-3-carboxylate

SMILES

COC(=O)[C@H]1CC2=C([C@H](N1C(=O)CCl)C3=CC4=C(C=C3)OCO4)NC5=CC=CC=C25

Matter Classification

organic

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