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Introduction:
Sugammadex is a kind of γ- Cyclodextrin derivative, whose molecule is composed of lipophilic core and hydrophilic outer end, is a selective muscle relaxant antagonist. Sugammadex is a modified γ- Cyclodextrin oligosaccharide, which takes synthetic cyclodextrin as the matrix and is water-soluble, is a round platform structure composed of lipophilic core and hydrophilic outer end. Through lipophilic core, sodium sugeng glucose can wrap steroid non depolarizing muscle relaxants (such as vecuronium and rocuronium), forming an inactive tight complex in the ratio of 1:1, so as to hinder the redistribution of muscle relaxants and accelerate the decomposition of steroid muscle relaxants and nicotinic acetylcholine receptors, Therefore, it can antagonize neuromuscular block at different depths. The complex is mainly distributed in the central chamber (plasma) and extracellular fluid, and is excreted in urine as a prototype. Sugammadex is highly water-soluble and biocompatible, which can directly remove the neuromuscular blocking effect of muscle relaxants at the neuromuscular junction. High selectivity and less side effects.
CAS：343306-79-6
Molecular formula: C72H104Na8O48S8
Molecular weight: 2178.01
Structural type:
Product Application:
Sugammadex is a selective muscle relaxant, which is mainly used in muscle spastic diseases and high muscle tension diseases. The drug has remarkable effect and quick effect.
Manufacturing
