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Linaelotide Acetate
Linaelotide Acetate / CAS : 851199-59-2
| Appearance | White to off white amorphous powder; Slightly soluble in water and sodium chloride aqueous solution (0.9%). | UN | 0 |
| HS | 30025100 | DG Class | 0 |
| Synonyms | Argpessin; Linzess; Linacllotide; Linaelotide; Cy-14; Liclotide; L-Tyrosine, L-Cysteinyl-L-Cysteinyl-L-α-Glutamyl-L-Tyrosyl-L-Cysteinyl-L-Cysteinyl-L-Asparaginyl-L-Prolyl-L-Alanyl-L-Cysteinyl-L-Threonylglycyl-L-Cysteinyl-, Cyclic (1→6),(2→10),(5→13)-tris(Disulfide); Linaclotide Acetate; Linaclotide | ||
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latest price
1/6
Packing:
0 KG/Customed Package
Audit
Hangzhou Holypharm Biotech Co.,Ltd.
Jiangsu, China
Overview
Benefits
High Quality: Linaclotide is produced by the biosynthesis process, without residual solvent, and with high purity.
Strong supply capacity: Compared with chemical synthesis, the production capacity of the biological synthesis process is not limited. The capacity of each batch can reach the kilogram level.
The lower price: The price of Linaclotide is 5%~10% lower than that of our competitors.
Specification
Test | Specification | Result |
Appearance | White or almost white powder | white powder |
Molecular | 1526.8±1 | 1527.35 |
Purity(HPLC) | ≥98.0% | Conforms |
Related substances(HPLC) | Total impurities:≤2.0% | Conforms |
Maximum single impurity:≤1.0% | Conforms | |
Water Content(Karl Fischer) | ≤8.0% | Conforms |
Acetonitrile | NTM 410 ppm | Conforms |
Acetate (HPLC) | NMT 5.0% | Conforms |
Host Cell Protein | ≤0.01% | Conforms |
Host Cell DNA | ≤10.0 ng/mg | Conforms |
Uses
Linaclotide, also known as Linaelotide acetate under the trade name Linzess, is a 14 amino acid synthetic peptide structurally related to the endogenous guanosine peptide family and is the only FDA-approved GC-C (guanylate cyclase-C) agonist class of drugs with local onset in the gut that can be used clinically to treat adult patients with constipation-predominant irritable bowel syndrome (IBS-C) and chronic idiopathic constipation (CIC).
Picture
Properties
Summary
Formula
C59H79N15O21S6
Molecular Mass
1526.74000
Exact Mass
1525.39000
PSA
725.71000
Logp
-0.59300
IUPAC
(2S)-2-[[(1R,4S,7S,13S,16R,21R,24R,27S,30S,33R,38R,44S)-21-amino-13-(2-amino-2-oxoethyl)-27-(2-carboxyethyl)-44-[(1R)-1-hydroxyethyl]-30-[(4-hydroxyphenyl)methyl]-4-methyl-3,6,12,15,22,25,28,31,40,43,46,51-dodecaoxo-18,19,35,36,48,49-hexathia-2,5,11,14,23,26,29,32,39,42,45,52-dodecazatetracyclo[22.22.4.216,33.07,11]dopentacontane-38-carbonyl]amino]-3-(4-hydroxyphenyl)propanoic acid
SMILES
CC1C(=O)NC2CSSCC3C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(NC(=O)CNC(=O)C(NC2=O)C(C)O)C(=O)NC(CC4=CC=C(C=C4)O)C(=O)O)C(=O)NC(CSSCC(C(=O)N3)N)C(=O)NC(C(=O)N5CCCC5C(=O)N1)CC(=O)N)CC6=CC=C(C=C6)O)CCC(=O)O
Attribute classification
Matter Classification
organic
Category
API & Intermediate > Other Chemical Drugs
API & Intermediate > Digestive System Drugs
API & Intermediate > Digestive System Drugs
Chemical and Physical Properties
Melting Point
231-235°C (dec.)
Density
1.60
Boiling Point
2045.0±65.0 °C(Predicted)
Appearance
White to off white amorphous powder; Slightly soluble in water and sodium chloride aqueous solution (0.9%).
Export information
HS Code
30025100
Export Rebate
13%
UN No.
0
DG-Class
0
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